54737-24-5

Basic information

• Product Name: 5-Brom-4-hydroxy-3-methoxy-β-nitrostyrol
• Synonyms: 5-Brom-4-hydroxy-3-methoxy-β-nitrostyrol
• CAS NO: 54737-24-5
• Molecular Weight: 274.071
• Mol File: 54737-24-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Brom-4-hydroxy-3-methoxy-β-nitrostyrol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Brom-4-hydroxy-3-methoxy-β-nitrostyrol(54737-24-5)
• EPA Substance Registry System: 5-Brom-4-hydroxy-3-methoxy-β-nitrostyrol(54737-24-5)

Safety Data

• Hazardous Substances Data: 54737-24-5(Hazardous Substances Data)

Upstream product

• 121-33-5 vanillin 
• 75-52-5 nitromethane 
• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 

Relevant articles and documents

Chemoselective zinc/HCl reduction of halogenated β-nitrostyrenes: Synthesis of halogenated dopamine analogues

A detailed account regarding the synthesis of 2- and 5-halogenated dopamine is given. The key step is a chemoselective reduction of a nitrostyrene by Zn/HCl at 0 °C. These conditions represent a simple, low-cost alternative to reduction by water-sensitive hydride donors and two-step procedures. Under these conditions, aryl fluoride, chloride, and bromide groups are stable. However, iodine undergoes significant reductive dehalogenation.