54758-71-3Relevant articles and documents
2-Hydroxybenzophenone as a Chemical Auxiliary for the Activation of Ketiminoesters for Highly Enantioselective Addition to Nitroalkenes under Bifunctional Catalysis
Guerrero-Corella, Andrea,Esteban, Francisco,Iniesta, Manuel,Martín-Somer, Ana,Parra, Mario,Díaz-Tendero, Sergio,Fraile, Alberto,Alemán, Jose
, p. 5350 - 5354 (2018)
An organocatalytic system is presented for the Michael addition of monoactivated glycine ketimine ylides with a bifunctional catalyst. The ketimine bears an ortho hydroxy group, which increases the acidity of the methylene hydrogen atoms and enhances the reactivity, thus allowing the synthesis of a large variety of α,γ-diamino acid derivatives with excellent stereoselectivity.
Asymmetric Transfer Hydrogenation of o-Hydroxyphenyl Ketones: Utilizing Directing Effects That Optimize the Asymmetric Synthesis of Challenging Alcohols
Clarkson, Guy J.,Wills, Martin,Zheng, Ye
supporting information, (2020/05/05)
A systematic range of o-hydroxyphenyl ketones were reduced under asymmetric transfer hydrogenation conditions using the C3-tethered catalyst 2. Two directing effects, i.e., an o-hydroxyphenyl coupled to a bulky aromatic on the opposite side of the ketone substrate, combine in a matched manner to deliver reduction products with very high enantiomeric excess.
Intramolecular hydrogen-bond activation for the addition of nucleophilic imines: 2-hydroxybenzophenone as a chemical auxiliary
Choubane, Houcine,Garrido-Castro, Alberto F.,Alvarado, Cuauhtemoc,Martín-Somer, Ana,Guerrero-Corella, Andrea,Daaou, Mortada,Díaz-Tendero, Sergio,Carmen Maestro,Fraile, Alberto,Alemán, José
supporting information, p. 3399 - 3402 (2018/04/05)
The addition of nucleophilic imines, using 2-hydroxybenzophenone as a chemical auxiliary, is presented. An intramolecular six-membered ring via hydrogen bonding that enhances the reactivity and selectivity is the key of this strategy, which is supported b
