548-58-3 Usage
Description
5,8-Dihydroxyflavone is a type of dihydroxyflavone, which is a flavone molecule substituted by hydroxy groups at positions 5 and 8. It is a naturally occurring compound found in various plants and has been studied for its potential biological activities and applications.
Uses
Used in Pharmaceutical Industry:
5,8-Dihydroxyflavone is used as a pharmaceutical compound for its potential therapeutic properties. It has been investigated for its antioxidant, anti-inflammatory, and anticancer activities, making it a promising candidate for the development of new drugs targeting various diseases.
Used in Cosmetic Industry:
In the cosmetic industry, 5,8-Dihydroxyflavone is used as an active ingredient for its antioxidant and anti-inflammatory properties. It can be incorporated into skincare products to help protect the skin from environmental stressors, reduce inflammation, and promote a healthy skin appearance.
Used in Nutraceutical Industry:
5,8-Dihydroxyflavone is also used in the nutraceutical industry as a dietary supplement due to its potential health benefits. It can be found in products that aim to support overall health and well-being by providing antioxidant and anti-inflammatory support.
Used in Research and Development:
5,8-Dihydroxyflavone is utilized in research and development for its potential applications in various fields, including pharmaceuticals, cosmetics, and nutraceuticals. Scientists and researchers are continually exploring its properties and potential uses to develop new products and therapies.
Synthesis Reference(s)
The Journal of Organic Chemistry, 49, p. 645, 1984 DOI: 10.1021/jo00178a013
Check Digit Verification of cas no
The CAS Registry Mumber 548-58-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 548-58:
(5*5)+(4*4)+(3*8)+(2*5)+(1*8)=83
83 % 10 = 3
So 548-58-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H10O4/c16-10-6-7-11(17)15-14(10)12(18)8-13(19-15)9-4-2-1-3-5-9/h1-8,16-17H
548-58-3Relevant articles and documents
Structure-activity relationships for α-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: The effect of A-ring substitution
Gao, Hong,Nishioka, Tetsuo,Kawabata, Jun,Kasai, Takanori
, p. 369 - 375 (2007/10/03)
In order to estimate the effects of the A-ring hydroxyl group of baicalein (5,6,7-trihydroxyflavone, 1) on rat intestinal α-glucosidase inhibition, flavone, monohydroxyflavones, dihydroxyflavones, and methylated derivatives of 5,6,7-trihydroxyflavone were used for the structure-activity relationship (SAR) study. The importance of the 6-hydroxyl group of baicalein was validated for an exertion of the activity. And also, the tested flavones which lacked a hydroxyl substituent on any of positions 5, 6, or 7, showed no activity. Hence, the 5,6,7-trihydroxyflavone structure was concluded to be crucial for the potent inhibitory activity. In addition, an introduction of electron-withdrawing or electron-donating groups at position 8 of baicalein led to a dramatic decrease for activity, except for 8-fluoro-5,6,7-trihydroxyflavone, which carried a less bulky substituent on position 8. Hence, this result suggested that a sterically bulky substituent on C-8 of baicalein was detrimental for the activity regardless of its electronic nature. Through examining the inhibitory mechanism of baicalein against rat intestinal α-glucosidase, it was suggested to be a mixed type inhibition.
