54807-44-2

Basic information

• Product Name: 4-(methylsulfanyl)-6-phenylpyrimidin-2-amine
• Synonyms: 4-(methylsulfanyl)-6-phenylpyrimidin-2-amine
• CAS NO: 54807-44-2
• Molecular Weight: 217.294
• Mol File: 54807-44-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(methylsulfanyl)-6-phenylpyrimidin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(methylsulfanyl)-6-phenylpyrimidin-2-amine(54807-44-2)
• EPA Substance Registry System: 4-(methylsulfanyl)-6-phenylpyrimidin-2-amine(54807-44-2)

Safety Data

• Hazardous Substances Data: 54807-44-2(Hazardous Substances Data)

Upstream product

• 34441-01-5 N-(1-phenylethylidene)cyanamide 
• 124-46-9 guanidine hydrogen carbonate 
• 13636-88-9 3,3-bis(methylthio)-1-phenylprop-2-en-1-one 
• 142386-64-9 2-Amino-4-methylthio-6-phenylpyrimidiniumchlorid 

Relevant articles and documents

Selective Cadmium Fluorescence Probe Based on Bis-heterocyclic Molecule and its Imaging in Cells

Fluorescence probes that selectively image cadmium are useful for detecting and tracking the amount of Cd2+ in cells and tissues. In this study, we designed and synthesized a novel Cd2+ fluorescence probe based on the pyridine-pyrimidine structure, 4-(methylsulfanyl)-6-(pyridin-2-yl)pyrimidin-2-amine (3), as a low-molecular-weight fluorescence probe for Cd2+. Compound 3 could successfully discriminate between Cd2+ and Zn2+ and exhibited a highly selective turn-on response toward Cd2+ over biologically related metal ions. The dissociation constant (Kd) and the limit of detection (LOD) of 5.4 × 10? 6?mol L? 1 and 4.4 × 10? 7?mol L? 1, respectively, were calculated using fluorescence titration experiments. Studies with closely related analogs showed that the bis-heterocyclic moiety of 3 acted as both a coordination site for Cd2+ and a fluorophore. Further, the methylsulfanyl group of compound 3 is essential for achieving selective and sensitive Cd2+ detection. Fluorescence microscopy studies using living cells revealed that the cell membrane permeability of compound 3 is sufficient to detect intracellular Cd2+. These results indicate that novel bis-heterocyclic molecule 3 has considerable potential as a fluorescence probe for Cd2+ in biological applications.

The use of α ketoketene S,S diacetals for a novel pyrimidine synthesis

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