54808-30-9

Basic information

• Product Name: 4-hydroxy-3-nitronaphthalene-1,2-dione
• CAS NO: 54808-30-9
• Molecular Formula: C₁₀H₅NO₅
• Molecular Weight: 219.1504
• Mol File: 54808-30-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 366.8°C at 760 mmHg
• Flash Point: 162.8°C
• Density: 1.63g/cm³
• Vapor Pressure: 5E-06mmHg at 25°C
• Refractive Index: 1.679
• CAS DataBase Reference: 4-hydroxy-3-nitronaphthalene-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-3-nitronaphthalene-1,2-dione(54808-30-9)
• EPA Substance Registry System: 4-hydroxy-3-nitronaphthalene-1,2-dione(54808-30-9)

Safety Data

• Hazardous Substances Data: 54808-30-9(Hazardous Substances Data)

Upstream product

• 117-80-6 2,3-Dichloro-1,4-naphthoquinone 
• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 5908-27-0 potassium 1,2-naphthoquinone-4-sulphonate 
• 90-15-3 α-naphthol 
• 13302-67-5 naphthalene-1,2,4-triol 
• 20513-06-8 2-amino-[1,4]naphthoquinone-4-imine 

Downstream Products

• 88-99-3 benzene-1,2-dicarboxylic acid 
• 74-90-8 hydrogen cyanide 
• 63388-44-3 2-phenyl-4,9-dioxo-4,9-dihydro-naphtho[2,3-d]oxazole 

Relevant articles and documents

A new method for the synthesis of 2-hydroxy-3-nitro-1,4-naphthoquinones: Application to regiospecific preparation of unsymmetrical nitrobiquinones

Novel 2-hydroxy-3-nitro-1,4-naphthoquinones were synthesized by an improved method utilizing nitronium tetrafluoroborate in high yields. A subsequent conversion to 2-chloro-3-nitro-1,4-naphthoquinones and a substitution of the chlorine by hydroxyquinone anions yielded 3-nitro-2,2′-binaphthoquinones with a complete regiocontrol.

Compounds and methods for treating cancer

Provided are small molecule inhibitors of ubiquitin specific protease 2, 8 and 12 (USP2 and USP8 and USP12) activity and methods for their use in treating cancers. The small molecule inhibitors of the invention are particularly useful in the treatment of non-small cell lung cancers that are resistant to tyrosine kinase inhibitors and in the treatment of prostate cancer that is resistant to AR inhibitor therapy.

2-Hydroxy-3-nitro-1,4-naphthoquinones

Substituted naphthoquinones of the formula (I) and pharmaceutically acceptable salts thereof wherein R1, R2, R3 and R4 represent alkyl, aryl, alkoxy, hydroxy, hydrogen or halogen or any two of the groups R1, R2, R3 and R4 taken together complete a carbocyclic ring, have useful anti-allergy activity in mammals.