54812-20-3

Basic information

• Product Name: 4-Acetoxymethyl-2,6-dimethyl-phenol
• Synonyms: 4-Acetoxymethyl-2,6-dimethyl-phenol
• CAS NO: 54812-20-3
• Molecular Weight: 194.23
• Mol File: 54812-20-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Acetoxymethyl-2,6-dimethyl-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Acetoxymethyl-2,6-dimethyl-phenol(54812-20-3)
• EPA Substance Registry System: 4-Acetoxymethyl-2,6-dimethyl-phenol(54812-20-3)

Safety Data

• Hazardous Substances Data: 54812-20-3(Hazardous Substances Data)

Upstream product

• 71655-87-3 4,4'-(oxybis(methylene))bis(2,6-dimethylphenol) 
• 64-19-7 acetic acid 
• 527-60-6 Mesitol 
• 4397-14-2 4-(hydroxymethyl)-2,6-dimethylphenol 
• 110-22-5 diacetyl peroxide 
• 45952-56-5 3,5-dimethyl-4-hydroxybenzyl bromide 
• 127-09-3 sodium acetate 
• 301-04-2 lead acetate 

Downstream Products

• 2233-18-3 4-hydroxy-3,5-dimethylbenzaldehyde 

Relevant articles and documents

Chemoselective oxidative generation of ortho-quinone methides and tandem transformations

ortho-Quinone methides are useful transient synthetic intermediates in organic synthesis. These species are most often generated in situ by the acid- or base-mediated transformation of phenols that have been pre-functionalized at a benzylic position, or by biomimetic oxidation of the corresponding ortho-alkylphenols with metal oxidants or transition-metal complexes. Here we describe a method for the transition-metal-free oxidative generation of o-QMs from ortho-alkylarenols, using hypoiodite catalysis under nearly neutral conditions, which can then be applied in one-pot tandem reactions. This method for the chemoselective oxidative generation of ortho-quinone methides may prove superior to previous methods with respect to environmental issues and scope, and can be applied to various tandem reactions such as inter- or intramolecular [4 + 2] cycloaddition, oxa-6π-electrocyclization, conjugate addition and spiroepoxidation. [Figure not available: see fulltext.].

PREPARATION OF ALKYLARYLCARBINOLS BY MONO-OXIDATION AT THE BENZYLIC POSITION USING 2,3-DICHLORO-5,6-DICYANOBENZOQUINONE (D.D.Q.)

A new and convenient method for the preparation of alkylarylacetates and alkylarylcarbinols is described.Monooxidation at the benzylic position was performed using 2,3-dichloro-5,6-dicyanobenzoquinone (D.D.Q.) in acetic acid.Good yields of arylcarbinols were obtained under mild conditions.