54814-43-6

Basic information

• Product Name: rosmarinic acid permethylate
• Synonyms: rosmarinic acid permethylate
• CAS NO: 54814-43-6
• Molecular Weight: 430.455
• Mol File: 54814-43-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: rosmarinic acid permethylate(CAS DataBase Reference)
• NIST Chemistry Reference: rosmarinic acid permethylate(54814-43-6)
• EPA Substance Registry System: rosmarinic acid permethylate(54814-43-6)

Safety Data

• Hazardous Substances Data: 54814-43-6(Hazardous Substances Data)

Upstream product

• 20283-92-5 (R)-(+)-rosmarinic acid 
• 77-78-1 dimethyl sulfate 
• 420-04-2 CYANAMID 
• 74-88-4 methyl iodide 
• 99353-00-1 rosmarinic acid methyl ester 

Downstream Products

• 457893-80-0 (-)-(R)-methyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate 
• 55757-14-7 (2S,3S)-methyl 2-(3,4-dimethoxyphenyl)-4-((E)-3-(((R)-3-(3,4-dimethoxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-methoxy-2,3-dihydrobenzofuran-3-carboxylate 
• 1310802-43-7 (2R,3R)-methyl 2-(3,4-dimethoxyphenyl)-4-((E)-3-(((R)-3-(3,4-dimethoxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-methoxy-2,3-dihydrobenzofuran-3-carboxylate 
• 35271-83-1 methyl 2-oxo 3-(3,4-dimethoxyphenyl) propanoate 
• 54814-41-4 (+/-)-(R)-methyl 3-(3,4-dimethoxyphenyl)-2-hydroxypropanoate 
• 868258-16-6 (2S,3S)-4-((E)-3-((R)-1-carboxy-2-(3,4-dimethoxyphenyl)ethoxy)-3-oxoprop-1-en-1-yl)-2-(3,4-dimethoxyphenyl)-7-methoxy-2,3-dihydrobenzofuran-3-carboxylic acid 
• 54814-41-4 3-(3,4-dimethoxy-phenyl)-2-hydroxy-propionic acid methyl ester 

Relevant articles and documents

Total synthesis of (+)-lithospermic acid by asymmetric intramolecular alkylation via catalytic C-H bond activation

The total synthesis of (+)-lithospermic acid is described. The efficient synthesis features an asymmetric alkylation via C-H bond activation to assemble the dihydrobenzofuran core of the natural product. This was accomplished via a chiral imine-directed C

Antimicrobial activity of Rosmarinus officinalis against oral pathogens: Relevance of carnosic acid and carnosol

The in vitro inhibitory activity of crude EtOH/H2O extracts from the leaves and stems of Rosmarinus officinalis L. was evaluated against the following microorganisms responsible for initiating dental caries: Streptococcus mutans, S. salivarius,

Improving the NQO1-Inducing Activities of Phenolic Acids from Radix Salvia miltiorrhiza: A Methylation Strategy

NAD(P)H: quinone oxidoreductase1 (NQO1) is an important detoxification enzyme that can protect mammalian cells against toxic quinones and reduce the risk of tumorigenesis. In this study, it was found that salvianolic acid B (SaB), lithospermic acid (LA), and rosmarinic acid (RA), three main hydrophilic constituents in Danshen, conjugated with glutathione (GSH) easily in vitro but exhibited no NQO1-inducing activities in Hepa 1c1c7 cells, which might attribute to their poor absorptions. After a simple methylation strategy that aimed at improving the liposolubility, both the NQO1-inducing activities and the absorptions in cells of the phenolic acids improved obviously, without losing the GSH-conjugating abilities. The concentration to double the specific activity of NQ01 values of methylated products of lithospermic acid and rosmarinic acid were 17.86±2.34μg/mL and 11.97± 0.60μg/mL, respectively. The findings indicated that methylation is an effective strategy to improve the NQO1-inducing activities of phenolic acids in Danshen. In the present study, a methylation strategy was employed to improve the NQO1 inducing activities of phenolic acids in Danshen. After methylation, both the NQO1 inducing activities and the absorptions in cells of the phenolic acids improved obviously without losing their GSH conjugating abilities.