54815-19-9

Basic information

• Product Name: N-(4-Methoxyphenethyl)acetamide
• Synonyms: N-(4-Methoxyphenethyl)acetamide;N-[2-(4-Methoxyphenyl)ethyl]acetamide
• CAS NO: 54815-19-9
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.24
• Mol File: 54815-19-9.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-Methoxyphenethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methoxyphenethyl)acetamide(54815-19-9)
• EPA Substance Registry System: N-(4-Methoxyphenethyl)acetamide(54815-19-9)

Safety Data

• Hazardous Substances Data: 54815-19-9(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 55-81-2 4-Methoxyphenethylamine 
• 75-36-5 acetyl chloride 
• 25413-27-8 3-(4-methoxy-phenyl)propionamide 
• 1202-66-0 N-acetyltyramine 
• 74-88-4 methyl iodide 
• 140-11-4 Benzyl acetate 
• 72-89-9 acetylcoenzyme A 
• 127-19-5 N,N-dimethyl acetamide 
• 108-05-4 vinyl acetate 
• 141-78-6 ethyl acetate 

Downstream Products

• 871894-82-5 N-(4-methoxyphenethyl)-N-methylacetamide 
• 41565-95-1 Methoxy-7 methyl-1 tetrahydro-1,2,3,4 isoquinoleine 
• 370-98-9 N-methyltyramine 
• 857945-29-0 N-(4-hydroxyphenethyl)-N-methylacetamide 
• 1976-98-3 (4-hydroxyphenethyl)trimethylammonium iodide 
• 154189-61-4 4-hydroxy-7-{2-[(2-{[3-(2-phenylethoxy)propyl]sulfonyl}ethyl)amino]ethyl}-1,3-benzothiazol-2(3H)-one 
• 212828-83-6 N-[(3-nitro-4-methoxyphenyl)ethyl]acetamide 
• 682738-60-9 N-[2-(3-amino-4-methoxyphenyl)ethyl]acetamide 

Relevant articles and documents

MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS

Provided herein, inter alia, are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Imidazolium chloride: An efficient catalyst for transamidation of primary amines

A highly efficient and convenient protocol of imidazolium chloride (30 mol %) catalyzed amidation of amines with moderate to excellent yields was reported. The protocol shows broad substrate scope for aromatic, aliphatic, and heterocyclic primary amines.

Mechanistic and structural analysis of Drosophila melanogaster arylalkylamine N-acetyltransferases

(Chemical Equation Presented). Arylalkylamine N-acetyltransferase (AANAT) catalyzes the penultimate step in the biosynthesis of melatonin and other N-acetylarylalkylamides from the corresponding arylalkylamine and acetyl-CoA. The N-acetylation of arylalkylamines is a critical step in Drosophila melanogaster for the inactivation of the bioactive amines and the sclerotization of the cuticle. Two AANAT variants (AANATA and AANATB) have been identified in D. melanogaster , in which AANATA differs from AANATB by the truncation of 35 amino acids from the N-terminus. We have expressed and purified both D. melanogaster AANAT variants (AANATA and AANATB) in Escherichia coli and used the purified enzymes to demonstrate that this N-terminal truncation does not affect the activity of the enzyme. Subsequent characterization of the kinetic and chemical mechanism of AANATA identified an ordered sequential mechanism, with acetyl-CoA binding first, followed by tyramine. We used a combination of pH-activity profiling and site-directed mutagenesis to study prospective residues believed to function in AANATA catalysis. These data led to an assignment of Glu-47 as the general base in catalysis with an apparent pKa of 7.0. Using the data generated for the kinetic mechanism, structure-function relationships, pH-rate profiles, and site-directed mutagenesis, we propose a chemical mechanism for AANATA.