54818-70-1

Basic information

• Product Name: (2E)-2-(methylimino)pyridin-1(2H)-ol
• CAS NO: 54818-70-1
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.1405
• Mol File: 54818-70-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 247.7°C at 760 mmHg
• Flash Point: 103.6°C
• Density: 1.1g/cm³
• Vapor Pressure: 0.00412mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: (2E)-2-(methylimino)pyridin-1(2H)-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-2-(methylimino)pyridin-1(2H)-ol(54818-70-1)
• EPA Substance Registry System: (2E)-2-(methylimino)pyridin-1(2H)-ol(54818-70-1)

Safety Data

• Hazardous Substances Data: 54818-70-1(Hazardous Substances Data)

Upstream product

• 2402-95-1 2-chloropyridine-N-oxide 
• 74-89-5 methylamine 
• 109-09-1 2-chloropyridine 

Downstream Products

• 54818-72-3 2-(Acetyl-methyl-amino)-pyridin-1-oxid 
• 108874-05-1 1-methoxy-1H-pyridin-2-one-methylimine; toluene-4-sulfonate 
• 19404-40-1 2-Methylamino-3,5-dinitropyridin 

Relevant articles and documents

Strategic Approach on N-Oxides in Gold Catalysis – A Case Study

An extensive kinetic study of selected key reactions of (oxidative) gold catalysis concentrates on the decrease of the catalytic activity due to inhibition of the gold(I) catalyst caused by pyridine derivatives that are obtained as by-products if N-oxides are applied as oxygen donors. The choice of the examined pyridine derivatives and their corresponding N-oxides has been made regardless of their commercial availability; particular attention has been paid to the practical benefit which up to now has been neglected in most of the reaction screenings. The test reactions were monitored by GC and 1H NMR spectroscopy. The received reaction constants provide information concerning a correlation between the electronic structure of the heterocycle and the catalytic activity. Based on the collected kinetic data, it was possible to develop a basic set of three N-oxides which have to be taken into account in further oxidative gold(I)-catalyzed reactions. (Figure presented.).

ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.