54833-77-1

Basic information

• Product Name: 3-(4-Nitrobenzylidene)-5-phenylfuran-2(3H)-one
• Synonyms: 3-(4-Nitrobenzylidene)-5-phenylfuran-2(3H)-one;3-[(4-Nitrophenyl)methylene]-5-phenyl-2(3H)-furanone
• CAS NO: 54833-77-1
• Molecular Formula: C₁₇H₁₁NO₄
• Molecular Weight: 293.2735
• Mol File: 54833-77-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 521.3°Cat760mmHg
• Flash Point: 237°C
• Appearance: /
• Density: 1.387g/cm³
• Vapor Pressure: 5.77E-11mmHg at 25°C
• Refractive Index: 1.696
• CAS DataBase Reference: 3-(4-Nitrobenzylidene)-5-phenylfuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Nitrobenzylidene)-5-phenylfuran-2(3H)-one(54833-77-1)
• EPA Substance Registry System: 3-(4-Nitrobenzylidene)-5-phenylfuran-2(3H)-one(54833-77-1)

Safety Data

• Hazardous Substances Data: 54833-77-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H11NO4/c19-17-14(10-12-6-8-15(9-7-12)18(20)21)11-16(22-17)13-4-2-1-3-5-13/h1-11H

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 2051-95-8 succinylbenzene 
• 1955-39-1 5-phenyl-3H-furan-2-one 

Downstream Products

• 77811-57-5 N-Benzyl-2-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-4-oxo-4-phenyl-butyramide 
• 77811-76-8 4-(4-Nitro-benzyl)-6-phenyl-2H-pyridazin-3-one 
• 77811-52-0 2-[1-(4-Nitro-phenyl)-meth-(Z)-ylidene]-4-oxo-4-phenyl-butyric acid hydrazide 
• 77811-85-9 1-benzyl-3-(4-nitrobenzylidene)-5-phenyl-1,3-dihydro-2H-pyrrol-2-one 
• 77811-74-6 2-[1-(4-Nitro-phenyl)-meth-(Z)-ylidene]-4-oxo-4-phenyl-butyric acid [1-phenyl-meth-(E)-ylidene]-hydrazide 

Relevant articles and documents

Synthesis of New Furanone Derivatives with Potent Anticancer Activity

Abstract: New compounds based on Furanone derivatives were synthesized by reaction of 3-(4-nitrobezylidine)-5-phenylfuran-2(3H)-one with various reagents as malononitrile then D-glucose, thiosemicarbazide then D-glucose, ethyl acetoacetate, acetyl acetone, ethyl cyanoacetate, hydrazine hydrate/acetic acid, thiourea, o-phenylene diamine, hydrazine hydrate/ethanol then 2-naphthalene thionylchloride and/or thiourea. Also, 3-(4-nitrobezylidine)-5-phenylfuran-2(3H)-one was reacted with benzyl amine to afford the 1,3-dihydro-2H-pyrrol-2-one derivative which was reacted with hydroxyl amine and/or phenyl hydrazine to afford compounds the oxazole and/or pyrazole derivatives respectively. Finely, 6-(4-nitrophenyl)-5-(2-oxo-2-phenylethyl)-2-thioxotetrahydro-pyrimidin-4(1H)-one was allowed to react with 2-oxo-N-phenylpropanehydrazonoyl chloride yielding [1,2,4]triazolo[4,3-a]pyrimidin-7(1H)-one derivative. The anti-cancer activity of some of some of the new synthesized compounds towards breast carcinoma cells (MCF-7) was evaluated that demonstrated good to moderate results. Also, we had evaluated the cytotoxicity of the new tested compounds against the normal cells (MRC-5) which showed low toxicity on them.

A highly efficient methodology for the synthesis of α-arylidene-γ-aryl-Δβ,γ-butenolides using microwaves

A highly efficient and practical methodology for the synthesis of α-arylidene-γ-aryl-Δβ,γ-butenolides is described starting from aryl propionic acids and aryl aldehydes under microwave conditions.