54866-65-8

Basic information

• Product Name: 1,2,4-Triazine-3(2H)-thione, 5,6-bis(4-methoxyphenyl)-
• CAS NO: 54866-65-8
• Molecular Formula: C17H15N3O2S
• Molecular Weight: 325.391
• Mol File: 54866-65-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1,2,4-Triazine-3(2H)-thione, 5,6-bis(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazine-3(2H)-thione, 5,6-bis(4-methoxyphenyl)-(54866-65-8)
• EPA Substance Registry System: 1,2,4-Triazine-3(2H)-thione, 5,6-bis(4-methoxyphenyl)-(54866-65-8)

Safety Data

• Hazardous Substances Data: 54866-65-8(Hazardous Substances Data)

Upstream product

• 119-52-8 4,4'-dimethoxybenzoin 
• 79-19-6 thiosemicarbazide 
• 1226-42-2 1,2-bis(4-methoxyphenyl)-1,2-ethanedione 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 58848-80-9 3-hydrazinyl-5,6-bis(4-methoxyphenyl)-1,2,4-triazine 
• 59663-59-1 1-[5,6-bis-(4-methoxy-phenyl)-[1,2,4]triazin-3-yl]-piperidin-4-ol 
• 59663-58-0 5,6-bis-(4-methoxy-phenyl)-3-(4-methyl-piperazin-1-yl)-[1,2,4]triazine 
• 54959-48-7 ethyl 2-((5,6-bis(4-methoxyphenyl)-1,2,4-triazin-3-yl)thio)acetate 

Relevant articles and documents

A new and facile synthesis of N-benzyl-N′-acylureas via reaction of dibenzoylhydrazine carboxamide and benzylamines

Herein, we report a new method of synthesis of N-acylureas (E1–5) via reaction of dibenzoylhydrazine carboxamide (N,2-bis(4-methoxybenzoyl)hydrazine-1-carboxamide) (C) and various benzylamines. Preparation of dibenzoylhydrazine carboxamide (C) was perform

Structure-based design, synthesis, molecular docking study and biological evaluation of 1,2,4-triazine derivatives acting as COX/15-LOX inhibitors with anti-oxidant activities

A set of 1,2,4-triazine derivatives were designed as cyclooxygenase-2 (COX-2) inhibitors. These compounds were synthesized and screened for inhibition of cyclooxygenases (COX-1 and COX-2) based on a cellular assay using human whole blood (HWB) and lipoxygenase (LOX-15) that are key enzymes in in?ammation. The results showed that 3-(2-(benzo[d][1,3]dioxol-5-ylmethylene)hydrazinyl)-5,6-bis(4-methoxyphenyl)-1,2,4-triazine (G11) was identified as the most potent COX-2 inhibitor (78%) relative to COX-1 (50%). Ferric reducing anti-oxidant power (FRAP) assay revealed that compound G10 possesses the highest anti-oxidant activity. The compound G3 with IC50 value of 124 μM was the most potent compound in LOX inhibitory assay. Molecular docking was performed and a good agreement was observed between computational and experimental results.

Design, synthesis and biological evaluation of novel anti-cytokine 1,2,4-triazine derivatives

A series of 16 novel 1,2,4-triazine derivatives bearing hydrazone moiety (7a-7p) have been designed, synthesized and evaluated for their activity to inhibit IL-1β and TNF-α production. All compounds are reported for the first time. The chemical structures of all compounds were confirmed by spectroscopic methods and elemental analyzes. Most of the synthesized compounds were proved to have potent anti-cytokine activity and low toxicity on PBMC and MCF-7 cell lines. Compounds 7f, 7k, 7l and 7j presented simultaneously good levels of inhibition of both cytokines. Moreover, compound 7l exhibited good anti-inflammatory effect in carrageenan-induced rat paw edema. The results of Western blotting demonstrated that the anti-cytokine potential of compound 7l is mainly mediated through the inhibition of p38 MAPK signaling pathway. Molecular docking was performed to position compound 7l into p38α binding site in order to explore the potential target. The information of this work might be helpful for the design and synthesis of novel scaffold toward the development of new therapeutic agent to fight against inflammatory diseases.