54874-26-9

Basic information

• Product Name: 3-(hydroxymethyl)-2-methylphenol
• Synonyms: 3-(hydroxymethyl)-2-methylphenol;EOS-60983
• CAS NO: 54874-26-9
• Molecular Formula: C₈H₁₀O₂
• Molecular Weight: 138.1638
• Mol File: 54874-26-9.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(hydroxymethyl)-2-methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(hydroxymethyl)-2-methylphenol(54874-26-9)
• EPA Substance Registry System: 3-(hydroxymethyl)-2-methylphenol(54874-26-9)

Safety Data

• Hazardous Substances Data: 54874-26-9(Hazardous Substances Data)

Usage

General Description

3-(hydroxymethyl)-2-methylphenol, also known as guaiacol, is a chemical compound that contains a hydroxyl group and a methoxy group attached to a benzene ring. It is commonly used as a starting material in the synthesis of various pharmaceuticals, such as the antitussive drug guaifenesin. Guaiacol also has applications in the flavor and fragrance industry, where it is used as a precursor to various flavor compounds. Additionally, it has antimicrobial properties and is used in the preservation of food and beverages. In the medical field, guaiacol is used as an expectorant and as a topical antiseptic for the treatment of various skin conditions.

Upstream product

• 603-80-5 3-hydroxy 2-methylbenzoic acid 

Downstream Products

• 870062-58-1 [2-methyl-3-(pyridin-2-yloxy)-phenyl]-methanol 
• 1255206-72-4 6-bromo-3-hydroxy-2-methylbenzenemethanol 
• 1310698-28-2 Isopropyl 2-[3-(hydroxymethyl)-2-methylphenoxy]acetate 
• 1255206-70-2 4-methyl-5-[2R-oxiran-2-yl]-2-benzofuran-1(3H)-one 
• 1194700-73-6 5-hydroxy-4-methyl-3H-isobenzofuran-1-one 
• 1255206-73-5 trifluoromethanesulfonic acid 4-methyl-1-oxo-1,3-dihydro-isobenzofuran-5-yl ester 
• 1255206-75-7 1,3-dihydro-1-oxo-4-methyl-5-(2-bromoacetyl)isobenzofuran 
• 1548289-28-6 (E)-4-methyl-5-(prop-1-en-1-yl)isobenzofuran-1(3H)-one 
• 1255206-67-7 5-bromo-4-methyl-2-benzofuran-1(3H)-one 
• 1255206-69-9 5-ethenyl-4-methyl-2-benzofuran-1(3H)-one 

Relevant articles and documents

Bio- And Chemocatalysis for the Synthesis of Late Stage SAR-Enabling Intermediates for ROMK Inhibitors and MK-7145 for the Treatment of Hypertension and Heart Failure

A synthetic strategy to provide two late-stage intermediates for the synthesis of diverse analogues of ROMK inhibitors for the treatment of hypertension and heart failure is described. Key transformations include carbonylation of a bromoarene, regioselect

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.