548756-56-5

Basic information

• Product Name: tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate
• Synonyms: tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate
• CAS NO: 548756-56-5
• Molecular Weight: 280.321
• Mol File: 548756-56-5.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate(548756-56-5)
• EPA Substance Registry System: tert-butyl 3-hydroxy-3-(2-hydroxy-3-methoxyphenyl)-2-methylenenpropanoate(548756-56-5)

Safety Data

• Hazardous Substances Data: 548756-56-5(Hazardous Substances Data)

Upstream product

• 548756-55-4 tert-butyl 3-hydroxy-3-(2-hydroxyphenyl)-2-methylenenpropanoate 
• 1663-39-4 tert-Butyl acrylate 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 548756-59-8 tert-butyl 3-(3,5-dibromo-2-hydroxyphenyl)-3-hydroxy-2-methylenenpropanoate 
• 548756-57-6 tert-butyl 3-(3-ethoxy-2-hydroxyphenyl)-3-hydroxy-2-methylenenpropanoate 
• 548756-58-7 tert-butyl 3-(5-bromo-2-hydroxyphenyl)-3-hydroxy-2-methylenenpropanoate 

Downstream Products

• 548756-55-4 tert-butyl 3-hydroxy-3-(2-hydroxyphenyl)-2-methylenenpropanoate 
• 548756-58-7 tert-butyl 3-(5-bromo-2-hydroxyphenyl)-3-hydroxy-2-methylenenpropanoate 
• 548756-57-6 tert-butyl 3-(3-ethoxy-2-hydroxyphenyl)-3-hydroxy-2-methylenenpropanoate 
• 515159-98-5 3-(chloromethyl)-8-methoxycoumarin 
• 57543-59-6 8-methoxy-2H-chromene-3-carboxylic acid 
• 1663-39-4 tert-Butyl acrylate 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 

Relevant articles and documents

Activated Self-Resolution and Error-Correction in Catalytic Reaction Networks**

Understanding the emergence of function in complex reaction networks is a primary goal of systems chemistry and origin-of-life studies. Especially challenging is to create systems that simultaneously exhibit several emergent functions that can be independently tuned. In this work, a multifunctional complex reaction network of nucleophilic small molecule catalysts for the Morita-Baylis-Hillman (MBH) reaction is demonstrated. The dynamic system exhibited triggered self-resolution, preferentially amplifying a specific catalyst/product set out of a many potential alternatives. By utilizing selective reversibility of the products of the reaction set, systemic thermodynamically driven error-correction could also be introduced. To achieve this, a dynamic covalent MBH reaction based on adducts with internal H-transfer capabilities was developed. By careful tuning of the substituents, rate accelerations of retro-MBH reactions of up to four orders of magnitude could be obtained. This study thus demonstrates how efficient self-sorting of catalytic systems can be achieved through an interplay of several complex emergent functionalities.

Application of Baylis-Hillman methodology in the direct construction of chromone derivatives

Pyridinium chlorochromate oxidation of Baylis-Hillman-derived tert-butyl 2H-chromene-3-carboxylates affords chromone-3-carboxylate esters, providing the first application of Baylis-Hillman methodology in a direct and convenient three-step synthesis of chr

Synthesis and evaluation of 3-hydroxy-3-phenylpropanoate ester-AZT conjugates as potential dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors

Novel 3-hydroxy-3-phenylpropanoate ester-azidothymidine (AZT) conjugates have been prepared using Baylis-Hillman methodology, and their potential as dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors has been explored using enzyme inhibition