54879-77-5

Basic information

• Product Name: N-(4-methoxybenzyl)aminoacetaldehyde dimethyl acetal
• Synonyms: N-(4-methoxybenzyl)aminoacetaldehyde dimethyl acetal
• CAS NO: 54879-77-5
• Molecular Weight: 225.288
• Mol File: 54879-77-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: N-(4-methoxybenzyl)aminoacetaldehyde dimethyl acetal(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxybenzyl)aminoacetaldehyde dimethyl acetal(54879-77-5)
• EPA Substance Registry System: N-(4-methoxybenzyl)aminoacetaldehyde dimethyl acetal(54879-77-5)

Safety Data

• Hazardous Substances Data: 54879-77-5(Hazardous Substances Data)

Upstream product

• 51673-84-8 dimethoxyacetaldehyde 
• 2393-23-9 4-methoxy-benzylamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 22483-09-6 2,2-dimethoxyethylamine 
• 54879-50-4 (2,2-Dimethoxy-ethyl)-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-amine 

Downstream Products

• 52986-70-6 6-methoxyisoquinoline 
• 54879-35-5 N-(2,2-Dimethoxy-ethyl)-N-(4-methoxy-benzyl)-4-methyl-benzenesulfonamide 
• 1083074-21-8 C₃₆H₃₈N₂O₆ 
• 95333-64-5 1-(4'-hydroxybenzyl)-2-thioimidazole 
• 250138-05-7 (2R,6R/S)-(+)-(6-methoxy-4-p-methoxybenzyl-3-oxomorpholin-2-yl)-(R)-hydroxyacetic acid methyl ester 
• 250137-80-5 methyl (1R,5S,7R)-3-(p-methoxybenzyl)-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-exo-carboxylate 
• 95460-09-6 1-(4-methoxybenzyl)imidazole-2-thione 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Imidazopyrazinone Derivatives as Antagonists of Inhibitor of Apoptosis Proteins (IAPs)

Apoptosis inhibitor (IAP) proteins are overexpressed in many cancers and implicated in tumor growth, so the development of antagonist that disrupts with the binding of IAP to their partner protein is a promising therapeutic strategy. In an effort to incre

Synthesis of 1,2-Dihydroisoquinolines by a Modified Pomeranz-Fritsch Cyclization

Isoquinolines (IQs) and their derivatives are present in many natural products and biologically active small molecules. Herein, we report a modified procedure for the classical Pomeranz-Fritsch protocol, which expands the scope of 1,2-dihydroisoquinoline (DHIQ) products. 1,2-DHIQs are an attractive branch point for the synthesis of IQs, but because of their innate reactivity, they have remained difficult to prepare. We demonstrate that the Fujioka/Kita conditions, combining trimethylsiyltriflate (TMSOTf) and an amine base, activate dimethylacetals required for Pomeranz-Fritsch cyclization under sufficiently mild conditions to prepare a broad range of 1,2-DHIQ products. We also demonstrate the synthetic value of these DHIQs by further functionalization to either reduced tetrahydroisoquinoline (THIQ) or fully aromatized IQ natural products.

Multisubstrate inhibitors of dopamine β-hydroxylase. 2. Structure-activity relationships at the phenethylamine binding site

-