54879-94-6

Basic information

• Product Name: 1H-Indole, 1,2,3-triphenyl-
• CAS NO: 54879-94-6
• Molecular Formula: C26H19N
• Molecular Weight: 345.444
• Mol File: 54879-94-6.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 1,2,3-triphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 1,2,3-triphenyl-(54879-94-6)
• EPA Substance Registry System: 1H-Indole, 1,2,3-triphenyl-(54879-94-6)

Safety Data

• Hazardous Substances Data: 54879-94-6(Hazardous Substances Data)

Usage

Molecular structure

1H-Indole, 1,2,3-triphenylconsists of a 1H-indole molecule with three phenyl groups attached to its 1, 2, and 3 positions.

Usage

It is commonly used in organic synthesis and pharmaceutical research as a versatile building block for the construction of various indole-based compounds and drug molecules.

Benefits

The presence of the phenyl groups on the indole core provides added structural diversity and potential for specific interactions with biological targets, making it a valuable starting material for the development of new drugs and molecular probes.

Potential applications

The triphenyl-substituted indole derivatives may exhibit interesting physical and chemical properties, which could find applications in material science and other fields of study.

Importance

1H-Indole, 1,2,3-triphenylis an important compound with diverse potential applications in science and industry.

Upstream product

• 1585241-19-5 1,2,3-triphenylindolin-3-ol 
• 5722-91-8 1,2-diphenyl-2-(phenylamino)ethanone 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 62-53-3 aniline 
• 501-65-5 diphenyl acetylene 
• 603-35-0 triphenylphosphine 
• 591-50-4 iodobenzene 
• 122-39-4 diphenylamine 
• 16483-98-0 2,3-diphenyl-2H-azirine 
• 861593-95-5 2-isobutylidene-1,1-diphenylhydrazine 
• 382165-80-2 N-nitrosodiphenylamine 
• 20877-86-5 N-phenyl isatoic anhydride 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 108-86-1 bromobenzene 

Downstream Products

• 29670-64-2 N-(2-benzoylphenyl)benzamide 
• 54880-08-9 9-phenyl-9H-dibenzocarbazole 
• 3469-20-3 2,3-diphenyl-1H-indole 

Relevant articles and documents

Nickel-catalyzed decarbonylative and decarboxylative cycloaddition of isatoic anhydrides with alkynes

We have developed a nickel-catalyzed cycloaddition of isatoic anhydrides with alkynes to afford 2,3-disubstituted indoles. The reaction proceeds via the elimination of carbon monoxide and carbon dioxide and the insertion of alkynes.

Assembly of Indole Cores through a Palladium-Catalyzed Metathesis of Ar-X σ-Bonds

We describe the development of a new method for construction of highly substituted indole scaffolds through the strategic utilizing of the metathesis of Ar-X σ-bonds based on the dynamic nature of palladium-based oxidative addition/reductive elimination. A suitable and simple catalytic system has provided an appropriate platform for a productive ligand exchange and consecutive carbopalladation/C-H activation/amination of phosphine ligands with alkynes and aromatic/aliphatic amines for construction of structurally diverse indoles.

A Fast Track to Indoles and Annulated Indoles through ortho- vs ipso-Amination of Aryl Halides

A complementary site selective ortho- vs ipso-amination of aryl halides using non-electrophilic amine sources for construction of indole scaffolds is reported. A palladium-catalyzed alkyne insertion/C-H activation/palladacycle amination via merger of three easily diversified components including iodoarenes, alkynes, and amines delivers indoles with different substitution patterns even in gram scales. By employing ortho-bromoanilines, a consecutive annulative π-extension of indoles proceeds to construct indolo[1,2-f]phenanthridine scaffolds via four C-C and C-N bond formations in one pot.