54881-13-9Relevant articles and documents
Preparation method of 2-[1-(ethyl sulfonyl)-3-azacyclic butyl] acetonitrile
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Paragraph 0066-0070, (2018/11/22)
The invention relates to the technical field of medical chemistry, and particularly relates to a preparation method of a baricotinib tetratomic ring intermediate, and also provides green oxidizing reaction performed in a micro-channel reactor. According to the method, the raw materials in the technical route are easily obtained; the method is economic, green, environmentally friendly and suitablefor industrial production.
ACID ADDITION SALTS OF SYNTHETIC INTERMEDIATES FOR CARBAPENEM ANTIBIOTICS AND PROCESSES FOR PREPARING THE SAME
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Page/Page column 8, (2010/12/26)
The present invention provides a process for preparing an acid addition salt of a synthetic intermediate for carbapenem antibiotics and a novel acid addition salt of a synthetic intermediate for carbapenem antibiotics obtained from the process. The present invention also provides a process for preparing a carbapenem antibiotic using the acid addition salt. According to the process of the present invention, an acid addition salt of a synthetic intermediate for carbapenem antibiotics can be prepared in a high yield and high purity, without conducting column chromatography. Thus, the process of the present invention can be applied to mass production with an industrial scale. Furthermore, since the acid addition salts have solid forms, they are easy to handle and keep in a manufacturing site.
2-ARYLMETHYLAZETIDINE CARBAPENEM DERIVATIVES AND PREPARATION THEREOF
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Page/Page column 19, (2008/06/13)
A 2-arylmethylazetidine carbapenem derivative of formula ( I ) or a pharmaceutically acceptable salt thereof exhibits a wide spectrum of antibacterial activities against Gram-positive and Gram-negative bacteria and excellent antibacterial activities against resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and quinolone-resistant strains (QRS).