54903-54-7

Basic information

• Product Name: Ethanone, 1-(4-amino-3-hydroxyphenyl)- (9CI)
• Synonyms: Ethanone, 1-(4-amino-3-hydroxyphenyl)- (9CI);Brn 2082470;Ethanone, 1-(4-amino-3-hydroxyphenyl)-;Jpb 12
• CAS NO: 54903-54-7
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16256
• Product Categories: ACETYLGROUP
• Mol File: 54903-54-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 170°C
• Boiling Point: 354.1°C at 760 mmHg
• Flash Point: 168°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 1.68E-05mmHg at 25°C
• Refractive Index: 1.613
• PKA: 8.94±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 1-(4-amino-3-hydroxyphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-amino-3-hydroxyphenyl)- (9CI)(54903-54-7)
• EPA Substance Registry System: Ethanone, 1-(4-amino-3-hydroxyphenyl)- (9CI)(54903-54-7)

Safety Data

• Hazardous Substances Data: 54903-54-7(Hazardous Substances Data)

Usage

Preparation

Preparation from 6-acetyl-2-(3H)-benzoxazolinone by alkaline hydrolysis with boiling 10% aqueous sodium hydroxide solution (90–100%).

InChI:InChI=1/C8H9NO2/c1-5(10)6-2-3-7(9)8(11)4-6/h2-4,11H,9H2,1H3

Upstream product

• 89942-63-2 1-(5-hydroxy-4-nitrophenyl)ethanone 
• 54903-09-2 6-acetyl-3H-benzooxazol-2-one 
• 59-49-4 2-Benzoxazolinone 
• 95-55-6 2-amino-phenol 

Downstream Products

• 84330-84-7 7-acetyl-3,4-dihydro-2H-1,4-benzoxazin-3-one 
• 1363159-52-7 1-(4-amino-3-n-butoxyphenyl)ethanone 
• 1363159-55-0 1-(4-amino-3-cyclohexyloxyphenyl)ethanone 
• 1363159-59-4 N-(4-acetyl-2-cyclohexyloxyphenyl)methanesulfonamide 
• 1363159-53-8 1-(4-amino-3-n-pentoxyphenyl)ethanone 
• 1363159-57-2 N-(4-acetyl-2-pentoxyphenyl)methanesulfonamide 
• 1363159-54-9 1-(4-amino-3-n-hexoxyphenyl)ethanone 
• 1363159-58-3 N-(4-acetyl-2-hexoxyphenyl)methanesulfonamide 
• 1363159-56-1 N-(4-acetyl-2-butoxyphenyl)methanesulfonamide 

Relevant articles and documents

HMOX1 inducers

The present invention is related to compounds of structure (I) as heme oxygenase 1 (HMOX 1) inducers. The present invention is also related a method of controlling the activity or the amount, or both the activity and the amount, of heme-oxygenase 1 in a mammalian subject. The definitions of the variables are provided herein.

Unequivocal Preparation of 4- and 5-Acyl-2-aminophenols

Unequivocal methods for the specific preparation of 4- or 5-acyl-2-aminophenols are reported. 5-Acyl-2-aminophenols are obtained by ring opening with dilute sodium hydroxide of 2(3H)-benzoxazolinones acylated at position 6. 4-Acyl-2-aminophenols are obtai