54927-71-8Relevant articles and documents
Efficient and practical protocol for silylation of hydroxyl groups using reusable lithium perchlorate dispread in silica gel under neutral condition
Azizi, Najmedin,Yousefi, Rozbeh,Saidi, Mohammad R.
, p. 817 - 820 (2006)
A very efficient and mild procedure for the trimethylsilylation of a wide variety of alcohols, including primary, allylic, benzylic, secondary, hindered secondary, tertiary, and phenols with hexamethyldisilazane on the surface of silica gel dispersed with LiClO4 in room temperature at few minutes in excellent yields under neutral conditions is reported. This procedure also allows the excellent selectivity under LP-SiO2 system for silylation of alcohols in the presence of amine and phenolic hydroxy groups.
An expeditious, efficient green methodology for the Boc protection of amines and silyl protection of alcohols over tungstophosphoric acid-doped mesoporous silica
Karmakar, Bikash,Banerji, Julie
experimental part, p. 3855 - 3858 (2010/08/20)
An efficient, chemoselective and eco-friendly protocol for the protection of amines as N-tert-butylcarbamate using (Boc)2O and protection of alcohols as silyl ether using HMDS over tungstophosphoric acid/SBA15 has been developed. Solventless condition, easy work-up, short reaction time, excellent yields and reusability of the catalyst are the striking features of this methodology which can be considered to be one of the better methods for the protection of amines and alcohols.
Lanthanum trichloride: An efficient catalyst for the silylation of hydroxyl groups by activating hexamethyldisilazane (HMDS)
Narsaiah, Akkirala Venkat
, p. 3614 - 3618 (2008/02/08)
A variety of hydroxy functional groups was protected as their corresponding trimethylsilyl ethers using HMDS in the presence of lanthanum trichloride. The catalyst LaCl3 activates the HMDS and accelerates the reaction under mild reaction conditions at room temperature to afford the corresponding silylated products in excellent yields.
