549506-47-0

Basic information

• Product Name: 4-CARBOXYMETHYL-3-OXO-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 4-BOC-1-CARBOXYMETHYL-PIPERAZIN-2-ONE;4-CARBOXYMETHYL-3-OXO-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-N-BOC-2-OXO-PIPERAZINE-1-ACETIC ACID;2-Oxo-4-BOC-1-piperazineacetic acid;4-Boc-2-oxo-piperazine-1-aceticacid;2-{4-[(tert-butoxy)carbonyl]-2-oxopiperazin-1-yl}acetic acid;-N-Boc-2-oxo-piperazine-1-aceticacid;4-[(1,1-Dimethylethoxy)carbonyl]-2-oxo-1-piperazineacetic acid
• CAS NO: 549506-47-0
• Molecular Formula: C₁₁H₁₈N₂O₅
• Molecular Weight: 258.27
• Mol File: 549506-47-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 456.2 °C at 760 mmHg
• Flash Point: 229.7 °C
• Appearance: /
• Density: 1.263
• Vapor Pressure: 1.37E-09mmHg at 25°C
• Refractive Index: 1.512
• Storage Temp.: Store at 0-5°C
• PKA: 3.66±0.10(Predicted)
• CAS DataBase Reference: 4-CARBOXYMETHYL-3-OXO-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CARBOXYMETHYL-3-OXO-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(549506-47-0)
• EPA Substance Registry System: 4-CARBOXYMETHYL-3-OXO-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(549506-47-0)

Safety Data

• Hazardous Substances Data: 549506-47-0(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C11H18N2O5/c1-11(2,3)18-10(17)13-5-4-12(7-9(15)16)8(14)6-13/h4-7H2,1-3H3,(H,15,16)

Upstream product

• 76003-29-7 4-(t-butyloxycarbonyl)piperazin-2-one 

Downstream Products

• 549506-52-7 2-[4-(4-chloro-benzenesulfonyl)-2-oxo-piperazin-1-yl]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide 

Relevant articles and documents

SUBSTITUTED HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF PAIN AND EPILEPSY

Compounds of formula (I) which are useful in ameliorating conditions characterized by unwanted sodium and/or calcium channel activity, particularly unwanted Nav 1.7, Nav 1.8, or Cav 3.2 channel activity are disclosed. Specifically, a series of compounds containing piperidine or piperazine linked through an amide, isoxazole or similar linker to an aryl ring are described and are shown to be useful for the treatment of pain or epilepsy. A is selected from Formulae (i) or (ii).