Cas 549520-67-4,3,4,5-triacetoxy-6-{2-[(4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yloxycarbonyl)-methyl-amino]-4-nitro-phenoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

549520-67-4

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Product Name: 3,4,5-triacetoxy-6-{2-[(4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yloxycarbonyl)-methyl-amino]-4-nitro-phenoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester
Synonyms: 3,4,5-triacetoxy-6-{2-[(4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yloxycarbonyl)-methyl-amino]-4-nitro-phenoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester
CAS NO:549520-67-4
Molecular Formula:
Molecular Weight: 902.822
EINECS: N/A
Product Categories: N/A
Mol File: 549520-67-4.mol
Article Data: 1

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 3,4,5-triacetoxy-6-{2-[(4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yloxycarbonyl)-methyl-amino]-4-nitro-phenoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester(CAS DataBase Reference)
NIST Chemistry Reference: 3,4,5-triacetoxy-6-{2-[(4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yloxycarbonyl)-methyl-amino]-4-nitro-phenoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester(549520-67-4)
EPA Substance Registry System: 3,4,5-triacetoxy-6-{2-[(4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yloxycarbonyl)-methyl-amino]-4-nitro-phenoxy}-tetrahydro-pyran-2-carboxylic acid methyl ester(549520-67-4)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 549520-67-4(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 549520-67-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,4,9,5,2 and 0 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 549520-67:
(8*5)+(7*4)+(6*9)+(5*5)+(4*2)+(3*0)+(2*6)+(1*7)=174
174 % 10 = 4
So 549520-67-4 is a valid CAS Registry Number.

549520-67-4Upstream product

86639-52-3 7-ethyl-10-hydroxycamptothecin

549520-67-4Downstream Products

549520-67-4Relevant articles and documents

Cancer chemotherapy: A SN-38 (7-Ethyl-10-hydroxycamptothecin) glucuronide prodrug for treatment by a PMT (Prodrug monoTherapy) strategy

Angenault, Stephane,Thirot, Sylvie,Schmidt, Frederic,Monneret, Claude,Pfeiffer, Bruno,Renard, Pierre

, p. 947 - 950 (2003)

A glucuronide-based prodrug of SN-38 (7-ethyl-10-hydroxycamptothecin) has been synthesized for use in a Prodrug MonoTherapy Strategy (PMT). Since this prodrug is significantly less cytotoxic than SN-38 itself and efficiently releases the drug in vitro in the presence of β-D-glucuronidase, it can be considered as an appropriate candidate for cancer treatment by a PMT strategy.

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