54978-55-1

Basic information

• Product Name: Phenyl 1,4-dihydroxy-2-naphthoate
• Synonyms: 1,4-DIHYDROXY-2-NAPHTHOIC ACID PHENYL ESTER;PHENYL 1,4-DIHYDROXY-2-NAPHTHOATE;SALOR-INT L203955-1EA;1,4-Dihydroxy-2-naphtoic acid phenyl ester;Dihydroxynaphtoicacidphenylester;1,4-DIHYDROXY-2-NAPHTHOIC ACID PHENYL;1,4-DIHYDROXY-2-NAPHTHOIC ACID PHENYL ESTER 98+%;Einecs 259-419-4
• CAS NO: 54978-55-1
• Molecular Formula: C₁₇H₁₂O₄
• Molecular Weight: 280.27
• EINECS: 259-419-4
• Product Categories: Intermediates of Dyes and Pigments;Naphthalene derivatives
• Mol File: 54978-55-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 156°C
• Boiling Point: 505.4 °C at 760 mmHg
• Flash Point: 191.8 °C
• Appearance: Yellow Powder
• Density: 1.375 g/cm³
• Vapor Pressure: 7.76E-11mmHg at 25°C
• Refractive Index: 1.708
• PKA: 8.39±0.50(Predicted)
• CAS DataBase Reference: Phenyl 1,4-dihydroxy-2-naphthoate(CAS DataBase Reference)
• NIST Chemistry Reference: Phenyl 1,4-dihydroxy-2-naphthoate(54978-55-1)
• EPA Substance Registry System: Phenyl 1,4-dihydroxy-2-naphthoate(54978-55-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 54978-55-1(Hazardous Substances Data)

Usage

General Description

Phenyl 1,4-dihydroxy-2-naphthoate is a chemical compound that belongs to the class of naphthoic acid derivatives. It is characterized by a phenyl group attached to the 1-position and two hydroxy groups at the 4-position of the naphthalene ring. Phenyl 1,4-dihydroxy-2-naphthoate is often used in the production of dyes, pigments, and fluorescent materials due to its ability to form stable complexes with metal ions. It also exhibits antioxidant properties and has been studied for its potential applications in pharmaceuticals and materials science. However, it is important to handle and use this compound with caution, as it can be harmful if ingested or inhaled and may cause skin and eye irritation upon contact.

InChI:InChI=1/C17H12O4/c18-15-10-14(16(19)13-9-5-4-8-12(13)15)17(20)21-11-6-2-1-3-7-11/h1-10,18-19H

Upstream product

• 31519-22-9 1,4-dihydroxy-2-naphthoic acid 
• 108-95-2 phenol 
• 101-02-0 triphenyl phosphite 

Downstream Products

• 1220707-81-2 phenyl 1,4-bis(trifluoromethylsulfonyloxy)-2-naphthoate 
• 1220707-82-3 phenyl 1,4-bis(3-fluorophenyl)-2-naphthoate 
• 1220707-83-4 phenyl 1,4-bis[4-(trifluoromethyl)phenyl]-2-naphthoate 
• 1220707-84-5 phenyl 1,4-bis(p-tolyl)-2-naphthoate 
• 1220707-85-6 phenyl 1,4-bis(3-methoxyphenyl)-2-naphthoate 
• 1220707-86-7 phenyl 1,4-bis(3-ethoxyphenyl)-2-naphthoate 
• 1220707-87-8 phenyl 1-(2-ethoxyphenyl)-4-(trifluoromethylsulfonyloxy)-2-naphthoate 
• 1220707-88-9 phenyl 1-(2,4-dimethoxyphenyl)-4-(trifluoromethylsulfonyloxy)-2-naphthoate 
• 1220707-89-0 phenyl 1-(2,6-dimethoxyphenyl)-4-(trifluoromethylsulfonyloxy)-2-naphthoate 
• 1220707-90-3 phenyl 1-(4-chlorophenyl)-4-(trifluoromethylsulfonyloxy)-2-naphthoate 
• 1220707-92-5 phenyl 4-(3,4-dimethoxyphenyl)-1-(4-fluorophenyl)-2-naphthoate 
• 1220707-93-6 phenyl 1-(2,4-dimethoxyphenyl)-4-p-tolyl-2-naphthoate 
• 1220707-94-7 phenyl 4-(3,4-dimethoxyphenyl)-1-(4-(trifluoromethyl)phenyl)-2-naphthoate 
• 1220707-95-8 phenyl 4-(4-methoxyphenyl)-1-(4-vinylphenyl)-2-naphthoate 

Relevant articles and documents

Re2O7 -catalyzed formal [3 + 2] cycloaddition for diverse naphtho[1,2-b]furan-3-carboxamides and their biological evaluation

Diverse naphtho[1,2-b]furan-3-carboxamide derivatives 12a–12q were synthesized in high yield via the novel Re2O7 -catalyzed formal [3+2] cycloaddition of 1,4-naphthoquinones with β-ketoamides as the key step. This methodology offers several advantages, such as environmentally benign character, the use of a mild catalyst, high yields, and ease of handling. The synthesized compounds were screened for their tyrosinase inhibitory, antioxidant, and antibacterial activities. The results showed that compound 12c exhibited excellent tyrosinase inhibitory activity with an IC50 of 13.48 μg/mL, which is comparable to that of kojic acid (IC50 = 19.45 μg/mL). Compounds 12a, 12b, and 12i displayed moderate antioxidant activities in a DPPH assay. Compound 12m showed good activity against S. aureus (MIC = 16 μg/mL), and compound 12p was found to be active against E. coli (MIC = 16 μg/mL).