54986-94-6 Usage
Description
[2-(2-THIENYL)-1,3-THIAZOL-4-YL]METHANOL is a chemical compound with the molecular formula C9H7NOS2, belonging to the thiazole derivative class. It features a thienyl group and a hydroxymethyl group, which contribute to its potential biological and pharmacological activities. [2-(2-THIENYL)-1,3-THIAZOL-4-YL]METHANOL is widely utilized in the synthesis of pharmaceuticals and agrochemicals, and its structural diversity allows it to serve as a building block in organic synthesis. Its properties and applications make [2-(2-THIENYL)-1,3-THIAZOL-4-YL]METHANOL a valuable compound in the fields of medicinal chemistry and materials science.
Uses
Used in Pharmaceutical Synthesis:
[2-(2-THIENYL)-1,3-THIAZOL-4-YL]METHANOL is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique chemical structure and potential biological activities. Its presence in the molecular structure of drugs can enhance their efficacy and pharmacological properties, making it a crucial component in drug development.
Used in Agrochemical Synthesis:
In the agrochemical industry, [2-(2-THIENYL)-1,3-THIAZOL-4-YL]METHANOL is used as a building block for the development of new agrochemicals. Its incorporation into the molecular structure of these chemicals can improve their effectiveness in pest control, crop protection, and other agricultural applications.
Used in Organic Synthesis:
As a thiazole derivative with structural diversity, [2-(2-THIENYL)-1,3-THIAZOL-4-YL]METHANOL is used as a versatile building block in organic synthesis. It can be employed in the creation of a wide range of organic compounds, contributing to the development of new materials and chemicals with various applications in different industries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, [2-(2-THIENYL)-1,3-THIAZOL-4-YL]METHANOL is used for its potential biological activities. Researchers utilize this compound in the design and development of new drugs, targeting various diseases and medical conditions. Its unique structure and properties make it a promising candidate for further exploration and application in medicinal chemistry.
Used in Materials Science:
[2-(2-THIENYL)-1,3-THIAZOL-4-YL]METHANOL also finds application in materials science, where it can be used to develop new materials with specific properties. Its incorporation into the molecular structure of these materials can enhance their performance, making them suitable for various applications, such as in electronics, coatings, and other advanced technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 54986-94-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,9,8 and 6 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 54986-94:
(7*5)+(6*4)+(5*9)+(4*8)+(3*6)+(2*9)+(1*4)=176
176 % 10 = 6
So 54986-94-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H7NOS2/c10-4-6-5-12-8(9-6)7-2-1-3-11-7/h1-3,5,10H,4H2
54986-94-6Relevant articles and documents
Single-step microwave-mediated synthesis of oxazoles and thiazoles from 3-oxetanone: A synthetic and computational study
Orr, David,Tolfrey, Alexandra,Percy, Jonathan M.,Frieman, Joanna,Harrison, Zo? A.,Campbell-Crawford, Matthew,Patel, Vipulkumar K.
, p. 9655 - 9662 (2013/07/26)
The direct microwave-mediated condensation between 3-oxetanone and primary amides and thioamides has delivered moderate to good yields of (hydroxymethyl)oxazoles and (hydroxymethyl)thiazoles. The reactions use a sustainable solvent and only require short reaction times. These are highly competitive methods for the construction of two classes of valuable heteroarenes, which bear a useful locus for further elaboration. Electronic structure calculations have shown that the order of events involves chalcogen atom attack at sp3 carbon and alkyl-oxygen cleavage. The critical role of acid catalysis was shown clearly, and the importance of acid strength was demonstrated. The calculated barriers were also fully consistent with the observed order of thioamide and amide reactivity. Spontaneous ring opening involves a modest degree of C-O cleavage, moderating the extent of strain relief. On the acid-catalysed pathway, C-O cleavage is less extensive still, but proton transfer to the nucleofuge is well advanced with the carboxylic acid catalysts, and essentially complete with methanesulfonic acid. Open sesame: The direct microwave-mediated condensation between 3-oxetanone and primary amides and thioamides has delivered moderate to good yields of oxazoles and thiazoles. The reactions use a sustainable solvent, require only short reaction times and represent a highly competitive method for the construction of two classes of valuable heteroarenes. Electronic structure calculations have been used to probe a range of potential reaction mechanisms (see figure). Copyright
Heterocyclic compounds, their production and use
-
, (2008/06/13)
Heterocyclic compounds represented by the general formula (I) wherein R stands for an optionally substituted aromatic heterocyclic group; X stands for oxygen atom, an optionally oxidated sulfur atom, —C(═O)— or —CH(OH)—; Y stands for CH or N; m denotes an integer of 0 to 10: n denotes an integer of 1 to 5: cyclic group ?stands for an optionally substituted aromatic azole group; and ring A is optionally further substituted, or salts thereof. The compound (I) possesses action of inhibiting tyrosine kinase and useful as antitumor agents.
