54997-90-9 Usage
Description
4-Isopropylbenzenesulfonyl chloride, also known as p-toluenesulfonyl chloride, is an organic compound derived from isopropylbenzene through chlorosulfonation. It is a clear yellow to orange liquid and is commonly used in the synthesis of various chemical compounds.
Uses
Used in Chemical Synthesis:
4-Isopropylbenzenesulfonyl chloride is used as a reagent for the synthesis of chlorosulfonyl-functionalized ATRP (Atom transfer radical polymerization) initiator. This initiator is essential in the controlled polymerization of various monomers, leading to the formation of well-defined polymers with specific molecular weights and architectures.
Additionally, 4-Isopropylbenzenesulfonyl chloride is used as a precursor in the synthesis of 4-isopropylbenzenethiol, which is an important intermediate in the production of various organic compounds and pharmaceuticals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Isopropylbenzenesulfonyl chloride is used as a key intermediate in the synthesis of various drugs and drug candidates. Its unique chemical properties allow for the development of novel therapeutic agents with specific biological activities.
Used in Polymer Science:
In the field of polymer science, 4-Isopropylbenzenesulfonyl chloride is used as a building block for the development of new polymer materials with tailored properties. These materials can be utilized in various applications, such as coatings, adhesives, and composites, due to their unique mechanical, thermal, and chemical properties.
Check Digit Verification of cas no
The CAS Registry Mumber 54997-90-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,9,9 and 7 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 54997-90:
(7*5)+(6*4)+(5*9)+(4*9)+(3*7)+(2*9)+(1*0)=179
179 % 10 = 9
So 54997-90-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H11ClO2S/c1-7(2)8-3-5-9(6-4-8)13(10,11)12/h3-7H,1-2H3
54997-90-9Relevant articles and documents
Facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides
Chen, Rongxiang,Xu, Shaohong,Shen, Fumin,Xu, Canran,Wang, Kaikai,Wang, Zhanyong,Liu, Lantao
, (2021/09/20)
A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields.
Ring inversion dynamics of derivatives of thianthrene di- and tetraoxide
Casarini, Daniele,Coluccini, Carmine,Lunazzi, Lodovico,Mazzanti, Andrea
, p. 6248 - 6250 (2007/10/03)
The ring inversion barrier for thianthrene tetraoxide was determined by making use of the variable temperature 13C NMR spectra of the 2,7-diisopropyl derivative (ΔG? = 6.5 kcal mol-1). The barrier is lower than that measured for a trans thianthrene dioxide derivative (ΔG? = 9.35 kcal mol-1). These results agree well with ab initio theoretical predictions.
Use of N-(4-aryl-thiazol-2-yl)-sulfonamides
-
, (2008/06/13)
The invention is concerned with the use of sulfonamide derivatives of the general formula STR1 wherein R signifies lower-alkyl, phenyl, benzyl, naphthyl, pyridyl or thienyl, optionally substituted by one or more lower-alkyl, lower-alkoxy, lower-alkyl carb
