55-51-6

Basic information

• Product Name: N,N-BIS(2-CHLOROETHYL)BENZENEMETHANAMINE
• Synonyms: N,N-BIS(2-CHLOROETHYL)BENZENEMETHANAMINE;benzylbis(beta-chloroethyl)amine;benzylnor-mechlorethamine;bis(2-chloroethyl)benzylamine;dcba;di-(2-chloroethyl)-benzylamine;n,n-bis(2-chloroethyl)-benzenemethanamin;n,n-bis(2-chloroethyl)-benzylamin
• CAS NO: 55-51-6
• Molecular Formula: C₁₁H₁₅Cl₂N
• Molecular Weight: 232.15
• Mol File: 55-51-6.mol
• Article Data: 39

Chemical Properties

• Melting Point: 148-150 °C
• Boiling Point: 371.94°C (rough estimate)
• Flash Point: 100.5 °C
• Appearance: /
• Density: 1.2093 (rough estimate)
• Vapor Pressure: 0.0336mmHg at 25°C
• Refractive Index: 1.6300 (estimate)
• PKA: 4.15±0.30(Predicted)
• CAS DataBase Reference: N,N-BIS(2-CHLOROETHYL)BENZENEMETHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-BIS(2-CHLOROETHYL)BENZENEMETHANAMINE(55-51-6)
• EPA Substance Registry System: N,N-BIS(2-CHLOROETHYL)BENZENEMETHANAMINE(55-51-6)

Safety Data

• Hazardous Substances Data: 55-51-6(Hazardous Substances Data)

Usage

Safety Profile

Poison by ingestion and possiblyother routes. Mutation data reported. When heated todecomposition it emits very toxic fumes of Cl- and NOx.

InChI:InChI=1/C11H15Cl2N/c12-6-8-14(9-7-13)10-11-4-2-1-3-5-11/h1-5H,6-10H2

Upstream product

• 101-32-6 N-benzyl-diethanolamine 
• 100-39-0 benzyl bromide 
• 334-22-5 N,N-bis(chloro-2-ethyl)amine 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 10429-82-0 N-benzyl-2-chloro-N-(2-chloroethyl)ethanamine hydrochloride 
• 100-52-7 benzaldehyde 
• 100-46-9 benzylamine 
• 100-44-7 benzyl chloride 
• 118753-70-1 N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine 

Downstream Products

• 109254-16-2 1-benzyl-4-(3-methoxy-phenyl)-piperidine-4-carbonitrile 
• 137059-25-7 N-benzyl-4-(phenylsulfonyl)piperidine 
• 99858-22-7 benzyl-bis-(2-chloro-ethyl)-amine oxide 
• 56243-25-5 1-benzyl-4-cyano-4-phenylpiperidine 
• 109505-97-7 1,1-diethyl-4-benzyl-piperazinium; chloride 
• 97095-89-1 1-diphenylmethyl-4-benzylpiperazine 
• 134697-67-9 1'-benzyl-3,4-dihydro-7-methoxy-2-oxospiro 
• 134697-66-8 1'-benzyl-3,4-dihydro-6-methyl-2-oxospiro 
• 134697-65-7 1'-benzyl-6-chloro-3,4-dihydro-2-oxospiro 
• 36080-66-7 8,19-dibenzyl-6,7,9,10,17,18,20,21-octahydrodibenzo-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane 
• 134697-63-5 1'-benzyl-3,4-dihydro-2-oxospiro 
• 123730-67-6 1-benzyl-4-cyano-4-ethoxycarbonylpiperidine 
• 137730-68-8 1'-benzyl-6,7,8,9-tetrahydro-6-oxospiro<5H-benzocycloheptene-5,4'-piperidine> 
• 218933-36-9 4-(4-benzyl-piperazin-1-yl)-1H-indole 

Relevant articles and documents

The synthesis of a di-N-heterocyclic carbene-amido complex of palladium(II)

A diimidazolium salt incorporating a secondary amine moiety has been used to prepare a palladium(II) di-N-heterocyclic carbene amino complex that can be deprotonated with NaH to give the first example of a transition metal NHC-amide.

QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF

Compounds and methods for their preparation and use as therapeutic or prophylactic agents, fo example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase- 1 (ENPP1).

NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS

This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.