55048-24-3

Basic information

• Product Name: 3-CHLORO-4-MORPHOLINOANILINE
• Synonyms: 3-CHLORO-4-MORPHOLINOANILINE;3-CHLORO-4-MORPHOLIN-4-YL-PHENYLAMINE;3-CHLORO-4-N-MORPHOLINOANILINE;AKOS B021988;AKOS BB-8568;LABOTEST-BB LT00511955;ASISCHEM T74566;BUTTPARK 44\09-56
• CAS NO: 55048-24-3
• Molecular Formula: C₁₀H₁₃ClN₂O
• Molecular Weight: 212.68
• EINECS: 259-456-6
• Mol File: 55048-24-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 102 °C
• Boiling Point: 399.1 °C at 760 mmHg
• Flash Point: 195.2 °C
• Appearance: /
• Density: 1.273 g/cm³
• Vapor Pressure: 1.41E-06mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: 2-8°C
• PKA: 6.00±0.40(Predicted)
• CAS DataBase Reference: 3-CHLORO-4-MORPHOLINOANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-MORPHOLINOANILINE(55048-24-3)
• EPA Substance Registry System: 3-CHLORO-4-MORPHOLINOANILINE(55048-24-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 55048-24-3(Hazardous Substances Data)

Usage

General Description

3-Chloro-4-morpholinoaniline is a chemical compound with the molecular formula C10H13ClN2O, which consists of a chloro group, a morpholino group, and an aniline group. It is commonly used as an intermediate in the production of various pharmaceuticals, dyes, and agrochemicals. 3-CHLORO-4-MORPHOLINOANILINE is known for its ability to act as a reagent in organic synthesis, participating in a variety of reactions such as nucleophilic substitution and aromatic substitution. It is important to handle 3-chloro-4-morpholinoaniline with caution and follow proper safety protocols due to its toxic and potentially harmful nature.

InChI:InChI=1/C10H13ClN2O/c11-9-7-8(12)1-2-10(9)13-3-5-14-6-4-13/h1-2,7H,3-6,12H2

Upstream product

• 55435-71-7 4-(2-chloro-4-nitrophenyl)morpholine 
• 350-30-1 3-chloro-4-fluoronitrobenzene 

Downstream Products

• 104686-94-4 (3-chloro-4-morpholin-4-yl-phenyl)-(7-methyl-1⁽³⁾H-imidazo[4,5-f]quinolin-9-yl)-amine 
• 442548-39-2 8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid (3-chloro-4-morpholin-4-yl-phenyl)-amide 
• 953040-05-6 tert-butyl 4-(5-bromo-2-(2-chloro-4-morpholin-4-yl-phenylamino)quinazolin-8-yloxy)-piperidine-1-carboxylate 
• 848133-15-3 6-amino-4-(3-chloro-4-morpholin-4-yl-phenylamino)-7-ethoxy-quinoline-3-carbonitrile 
• 442548-85-8 6-Fluoro-8-(4-methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid (3-chloro-4-morpholin-4-yl-phenyl)-amide 
• 442548-60-9 6-Methoxy-8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid (3-chloro-4-morpholin-4-yl-phenyl)-amide 
• 1071521-69-1 imidazole-1-carboxylic acid (3-chloro-4-morpholin-4-yl-phenyl)amide 
• 482305-72-6 5-Chloro-N-{[(5S)-3-(3-chloro-4-morpholinophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}-2-thiophenecarboxamide 
• 1101196-70-6 C₁₉H₂₆ClN₃O₅ 
• 1101196-72-8 C₂₀H₂₈ClN₃O₅ 
• 1542259-44-8 N-(3-chloro-4-morpholinophenyl)-3-oxobutanamide 
• 1542259-45-9 (2Z)-3-amino-N-(3-chloro-4-morpholinophenyl)but-2-enamide 
• 1542258-49-0 3-(3-chloro-4-morpholinophenyl)-2,6-dimethylpyrimidin-4(3H)-one 

Relevant articles and documents

SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a 6,5-heterocyclic structure (e.g., compounds having a imidazopyridine, imidazopyrimidine, imidazopyrazine, imidazopyridazine, imidazotriazine, benzoimidazole, benzotriazole, benzoisoxazole, purine, indazole, triazolotriazine, triazolopyridazine, triazolopyrimidine, triazolopyrazine, triazolotetrazine, triazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolopyridazine, pyrazolotriazine, pyrazolopyridine, isoxazolopyrazine, isoxazolopyrimidine, isoxazolopyrdiazine, isoxazolotriazine, or isoxalopyridine structure) which function as inhibitors of DYRK1A, DYRK1B, and Clk-1, and their use as therapeutics for the treatment of Alzheimer's disease, Down syndrome, diabetes, glioblastoma, autoimmune diseases, cancer (e.g., glioblastoma, prostate cancer), inflammatory disorders (e.g., airway inflammation), and other diseases.

PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE

The present invention deals with new flavivirus inhibitors, compositions comprising said inhibitors and methods for the treatment of disorders related to a viral infection, such as a disease due to a flavivirus infection, comprising administering said inhibitors.

Nitrogenous Heterocyclic Derivatives And Their Application In Drugs

The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.