55076-32-9

Basic information

• Product Name: methyl 3-hydroxy-5-nitro-benzoate
• Synonyms: methyl 3-hydroxy-5-nitro-benzoate
• CAS NO: 55076-32-9
• Molecular Formula: C₈H₇NO₅
• Molecular Weight: 197.15
• Mol File: 55076-32-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 154-156 °C
• Boiling Point: 377.2 °C at 760 mmHg
• Flash Point: 181.9 °C
• Appearance: /
• Density: 1.432 g/cm³
• Vapor Pressure: 3.17E-06mmHg at 25°C
• Refractive Index: 1.59
• PKA: 7.52±0.10(Predicted)
• CAS DataBase Reference: methyl 3-hydroxy-5-nitro-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-hydroxy-5-nitro-benzoate(55076-32-9)
• EPA Substance Registry System: methyl 3-hydroxy-5-nitro-benzoate(55076-32-9)

Safety Data

• Hazardous Substances Data: 55076-32-9(Hazardous Substances Data)

Usage

Description

Methyl 3-hydroxy-5-nitro-benzoate is a chemical compound derived from benzoic acid, characterized by the presence of a hydroxyl and nitro group at the 3rd and 5th positions respectively on the benzene ring. It is an organic ester with the molecular formula C8H7NO5.

Uses

Used in Synthetic Preparations:
Methyl 3-hydroxy-5-nitro-benzoate is used as an intermediate in the synthesis of various organic compounds. Its unique functional groups make it a versatile building block for creating a range of chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, methyl 3-hydroxy-5-nitro-benzoate is used as a key component in the development of new drugs. Its chemical structure allows for the creation of novel molecules with potential therapeutic applications.
Used in Chemical Research:
Methyl 3-hydroxy-5-nitro-benzoate is also utilized in chemical research for studying reaction mechanisms and exploring new synthetic pathways. Its reactivity and functional group chemistry provide valuable insights into organic chemistry and contribute to the advancement of the field.

InChI:InChI=1/C8H7NO5/c1-14-8(11)5-2-6(9(12)13)4-7(10)3-5/h2-4,10H,1H3

Upstream product

• 67-56-1 methanol 
• 78238-14-9 3-hydroxy-5-nitrobenzoic acid 
• 618-84-8 3-amino-5-nitro-benzoic acid 
• 99-34-3 3,5-dinitrobenzoic acid 
• 117342-20-8 (3-(methoxycarbonyl)-5-nitrophenyl)boronic acid 

Downstream Products

• 875846-14-3 3-butoxy-5-nitro-benzoic acid 
• 92010-01-0 methyl α-(tert-butoxycarbonyl)-5-nitro-m-anisate 
• 92054-18-7 methyl α-(tert-butoxycarbonyl)-5-amino-m-anisate 
• 92010-05-4 5-propionamido-α-carboxy-m-anisic acid 
• 92010-03-2 5-benzamido-α-carboxy-m-anisic acid 
• 92010-07-6 5-octanamido-α-carboxy-m-anisic acid 
• 92010-04-3 methyl α-(tert-butoxycarbonyl)-5-propionamido-m-anisate 
• 92010-09-8 5-(p-chlorobenzamido)-α-carboxy-m-anisic acid 
• 92010-13-4 5-(p-bromobenzamido)-α-carboxy-m-anisic acid 
• 92010-02-1 methyl α-(tert-butoxycarbonyl)-5-benzamido-m-anisate 
• 92010-06-5 methyl α-(tert-butoxycarbonyl)-5-octanamido-m-anisate 
• 92010-11-2 5-(3,4-dichlorobenzamido)-α-carboxy-m-anisic acid 
• 92010-08-7 methyl α-(tert-butoxycarbonyl)-5-(p-chlorobenzamido)-m-anisate 
• 92010-12-3 methyl α-(tert-butoxycarbonyl)-5-(p-bromobenzamido)-m-anisate 

Relevant articles and documents

Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists

Herein, we report studies leading to the discovery of the neoseptins and a comprehensive examination of the structure-activity relationships (SARs) of this new class of small-molecule mouse Toll-like receptor 4 (mTLR4) agonists. The compounds in this class, which emerged from screening an α-helix mimetic library, stimulate the immune response, act by a well-defined mechanism (mouse TLR4 agonist), are easy to produce and structurally manipulate, exhibit exquisite SARs, are nontoxic, and elicit improved and qualitatively different responses compared to lipopolysaccharide, even though they share the same receptor.

CRYSTALLINE FORMS OF TRICYCLIC COMPOUND ACID SALT OR HYDRATE THEREOF, AND METHOD FOR MAKING THEREOF

The present invention relates to a novel crystalline acid salt of a tricyclic derivative or a hydrate thereof and a production method thereof. The crystalline acid salt or the hydrate thereof according to the present invention is stable with respect to hu

NEOSEPTINS: SMALL MOLECULE ADJUVANTS

A MD-2:TLR4 complex agonist compound is disclosed whose structure corresponds to Formula (I), as defined within. Also disclosed are a method of its preparation and use, as well as a pharmaceutical composition containing the same.