55077-97-9

Basic information

• Product Name: 1H-Phenalen-1-one, 2-amino-
• Synonyms: 2-amino-1H-phenalen-1-one;2-Amino-phenalen-1-on;1H-Phenalen-1-one,2-amino;2-Amino-phenalenon;2-amino-phenalen-1-one;2-aminophenalenone;2-amino-1-phenalenone;2-Amino-1-phenalone
• CAS NO: 55077-97-9
• Molecular Formula: C13H9NO
• Molecular Weight: 195.221
• Mol File: 55077-97-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 127-128 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 410.4±45.0 °C(Predicted)
• Density: 1.319±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Phenalen-1-one, 2-amino-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Phenalen-1-one, 2-amino-(55077-97-9)
• EPA Substance Registry System: 1H-Phenalen-1-one, 2-amino-(55077-97-9)

Safety Data

• Hazardous Substances Data: 55077-97-9(Hazardous Substances Data)

Upstream product

• 548-39-0 Perinaphthenon 

Downstream Products

• 6642-29-1 4-nitronaphthalic-1,8-anhydride 
• 3352-83-8 2-bromo-1H-phenalen-1-one 
• 548-39-0 Perinaphthenon 

Relevant articles and documents

Design, synthesis and evaluation of amino-substituted 1H-phenalen-1-ones as anti-leishmanial agents

Screening of a designed collection of mono-substituted amino-1H-phenalen-1-ones against promastigote forms of L. donovani and L. amazonensis, identified seven compounds with anti-leishmanial activities comparable or better than the commonly prescribed anti-leishmanial drug, miltefosine. Structure-activity analysis revealed that appendages containing a basic tertiary nitrogen were favored, and that the position of the appendage also affected their potency. Like miltefosine, several of these active compounds significantly reduced the mitochondrial membrane potential in promastigotes. Further studies in amastigotes of L. amazonensis revealed that compounds 14, 15 and 33 were more active and more selective than miltefosine, with sub-micromolar potencies and selectivity indices >100.