55095-27-7

Basic information

• Product Name: bis[(4-fluorophenyl)methyl]amine
• Synonyms: bis[(4-fluorophenyl)methyl]amine;OTAVA-BB 1392929
• CAS NO: 55095-27-7
• Molecular Formula: C₁₃H₁₁F₂N
• Molecular Weight: 233.26
• Mol File: 55095-27-7.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 304.0±32.0 °C(Predicted)
• Appearance: /
• Density: 1.206±0.06 g/cm3(Predicted)
• PKA: 8.23±0.10(Predicted)
• CAS DataBase Reference: bis[(4-fluorophenyl)methyl]amine(CAS DataBase Reference)
• NIST Chemistry Reference: bis[(4-fluorophenyl)methyl]amine(55095-27-7)
• EPA Substance Registry System: bis[(4-fluorophenyl)methyl]amine(55095-27-7)

Safety Data

• Hazardous Substances Data: 55095-27-7(Hazardous Substances Data)

Upstream product

• 285129-93-3 Phenyl N-(4,4'-difluorobenzhydryl)carbamate 
• 363-02-0 4,4’-difluorobenzophenone oxime 
• 345-92-6 4,4'-Difluorobenzophenone 
• 365-24-2 4,4'-difluorobenzhydryl alcohol 
• 648893-89-4 N-[bis(4-fluorophenyl)methyl]formamide 
• 362-99-2 (4-fluorophenyl)-phenylmethanone oxime 
• 7705-07-9 titanium(III) chloride 
• 81123-44-6 (4-hydroxyphenyl)(phenyl)methanone oxime 
• 1194-02-1 4-fluorobenzonitrile 
• 352-13-6 4-flourophenylmagnesium bromide 
• 80529-17-5 4,4'-difluorobenzophenone imine 
• 457-68-1 4,4'-difluorodiphenylmethane 

Downstream Products

• 88535-59-5 N,N'-Diallyl-6-(4-{[bis-(4-fluoro-phenyl)-methyl]-amino}-piperidin-1-yl)-[1,3,5]triazine-2,4-diamine 
• 141528-05-4 N-Allyl-6-(4-{[bis-(4-fluoro-phenyl)-methyl]-amino}-piperidin-1-yl)-N'-propyl-[1,3,5]triazine-2,4-diamine 
• 88535-72-2 6-(4-{[Bis-(4-fluoro-phenyl)-methyl]-amino}-piperidin-1-yl)-N,N'-bis-((E)-but-2-enyl)-[1,3,5]triazine-2,4-diamine 
• 88551-62-6 N²,N⁴-Diallyl-6-(4-{[bis-(4-fluoro-phenyl)-methyl]-amino}-piperidin-1-yl)-pyrimidine-2,4-diamine 
• 1026196-20-2 (1S,3aS,3bS,9aR,9bS,11aS)-1-{[Bis-(4-fluoro-phenyl)-methyl]-carbamoyl}-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,7,8,9,9a,9b,10,11,11a-tetradecahydro-cyclopenta[i]phenanthridine-5-carboxylic acid tert-butyl ester 
• 116574-15-3 1-[Bis-(4-fluoro-phenyl)-methyl]-azetidin-3-ol 
• 211631-82-2 2-(1-Benzyl-piperidin-4-yl)-N-[bis-(4-fluoro-phenyl)-methyl]-acetamide 
• 190785-85-4 4-[2-(6-{[bis-(4-fluoro-phenyl)-methyl]-carbamoyl}-benzofuran-2-yl)-phenoxy]-butyric acid ethyl ester 
• 190785-74-1 4-[2-(5-{[bis-(4-fluoro-phenyl)-methyl]-carbamoyl}-benzofuran-2-yl)-phenoxy]-butyric acid ethyl ester 
• 878162-51-7 4,4'-difluorophenyl-methyl-isocyanate 
• 772331-22-3 N-[bis(4-fluorophenyl)methyl]-2-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)acetamide 
• 383362-71-8 4-[(Bis(4-fluorophenyl)methylamino)methyl]-1-[2-(phenyl)ethyl]piperidine 
• 116574-18-6 1-(4,4'-Difluorobenzhydryl)-3-azetidinyl cyanoacetate 
• 896127-64-3 tert-butyl 3-(2-{[bis(4-fluorophenyl)methyl]amino}-2-oxoethyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Electrochemical Oxidative C(sp3)-H/N-H Coupling of Diarylmethanes with Sulfoximines or Benzophenone Imine

Herein, we report an efficient electrochemical method for the synthesis of N-alkylated sulfoximines by electrochemical oxidative C(sp3)-H/N-H coupling of sulfoximines and diarylmethanes. In addition, we used the same conditions for electrochemical dehydrogenative amination of diarylmethanes with benzophenone imine as an aminating agent. The reactions showed good functional group tolerance and afforded the corresponding products in moderate to good yields without the use of a stoichiometric oxidant, a metal catalyst, or an activating agent.

DOPAMINE D2 RECEPTOR LIGANDS

The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-reiated orphan receptor gamma (RORy) modulators and their use in the treatment of diseases mediated by RORy.