55142-86-4

Basic information

• Product Name: Ticlopidine IMpurity G
• Synonyms: Ticlopidine IMpurity G
• CAS NO: 55142-86-4
• Molecular Formula: C14H14ClNS
• Molecular Weight: 263.78566
• Mol File: 55142-86-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 367.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.273±0.06 g/cm3(Predicted)
• PKA: 7.22±0.20(Predicted)
• CAS DataBase Reference: Ticlopidine IMpurity G(CAS DataBase Reference)
• NIST Chemistry Reference: Ticlopidine IMpurity G(55142-86-4)
• EPA Substance Registry System: Ticlopidine IMpurity G(55142-86-4)

Safety Data

• Hazardous Substances Data: 55142-86-4(Hazardous Substances Data)

Upstream product

• 272-14-0 thieno[3,2-c]pyridine 
• 620-20-2 1-Chloro-3-chloromethyl-benzene 

Relevant articles and documents

Preparation of 2-(2-thienyl) ethylamine and synthesis of thieno [3,2-C] pyridine derivatives therefrom

Compounds of the formulae:and wherein:, R1, R2, R3 and R4 are independently hydrogen, lower alkyl of one to six carbon atoms, aryl or substituted aryl;, are advantageously converted to isocyanurate compounds, 2-(2-thienyl)ethylamine compounds and thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.

2-(2-nitrovinyl)thiophene reduction and synthesis of thieno[3,2-c]pyridine derivatives

An improved process for the reduction of 2-(2-nitrovinyl)thiophene to form 2-(2-thienyl)ethylamine employs a boron-containing reducing agent, preferably diborane. The 2-(2-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.