5518-52-5 Usage
Description
TRI(2-FURYL)PHOSPHINE is a phosphine ligand that exists as a white to light yellow crystal powder. It is widely utilized in various organic synthesis processes, particularly in transition-metal mediated reactions, such as Wittig reactions and Suzuki reactions, where it enhances (Z) selectivity.
Uses
Used in Organic Synthesis:
TRI(2-FURYL)PHOSPHINE is used as a phosphine ligand for transition-metal mediated organic synthesis, specifically in Wittig reactions, to improve (Z) selectivity. This enhancement allows for the creation of more precise and desired products in chemical reactions.
Used in Suzuki Reaction:
In the field of cross-coupling reactions, TRI(2-FURYL)PHOSPHINE is employed as a phosphine ligand in the Suzuki reaction. This reaction is a widely used method for the formation of carbon-carbon bonds, particularly in the synthesis of complex organic molecules and pharmaceutical compounds.
Overall, TRI(2-FURYL)PHOSPHINE plays a crucial role in the advancement of organic chemistry, particularly in the development of new and efficient synthetic pathways for the production of various compounds.
Reaction
Useful ligand for C-C coupling reactions.
Ligand used for the alkynylation of thioesters.
Ligand used for enol ester formation.
Ligand for palladium-catalyzed 3-Component coupling.
Ligand for palladium-catalyzed C-C coupling reaction.
Ligand for trans-olefin formation.
Olefin formation from N-tosylhydrazones and benzyl halides.
C-H arylation/alkenylation of 1-substituted tetrazoles.
Check Digit Verification of cas no
The CAS Registry Mumber 5518-52-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,5,1 and 8 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5518-52:
(6*5)+(5*5)+(4*1)+(3*8)+(2*5)+(1*2)=95
95 % 10 = 5
So 5518-52-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H9O3P/c1-4-10(13-7-1)16(11-5-2-8-14-11)12-6-3-9-15-12/h1-9H
5518-52-5Relevant articles and documents
Synthesis of the tertiaryphosphine derivatives of iron carbonyl phosphines: preparation of tetracarbonyliron(0), pentacarbonylbisdiiron(0), tetracarbonyliron(0) and pentacarbonylbis<...
Santelli-Rouvier, Christiane,Coin, Christine,Toupet, Loic,Santelli, Maurice
, p. 91 - 96 (1995)
Pentacarbonyl iron reacts with this(2-furyl)phosphine (or tris(2-benzofuryl)phosphine) in the presence of sodium borohydride in refluxing n-butanol to give the title compounds.The crystal and molecular structure of pentacarbonylbis(μ-bis(2-furyl)phosphido>diiron(0) were determined by X-ray crystallography. Keywords: Iron; Dinuclear; Carbonyls; X-ray structure; Benzoferrylphosphine complex
The Trityl-Cation Mediated Phosphine Oxides Reduction
Landais, Yannick,Laye, Claire,Lusseau, Jonathan,Robert, Frédéric
supporting information, p. 3035 - 3043 (2021/05/10)
Reduction of phosphine oxides into the corresponding phosphines using PhSiH3 as a reducing agent and Ph3C+[B(C6F5)4]? as an initiator is described. The process is highly efficient, reducing a broad range of secondary and tertiary alkyl and arylphosphines, bearing various functional groups in generally good yields. The reaction is believed to proceed through the generation of a silyl cation, which reaction with the phosphine oxide provides a phosphonium salt, further reduced by the silane to afford the desired phosphine along with siloxanes. (Figure presented.).
Catalyst-free alcoholysis of phosphane-boranes: a smooth, cheap, and efficient deprotection procedure
Van Overschelde, Michel,Vervecken, Elias,Modha, Sachin G.,Cogen, Simon,Van der Eycken, Erik,Van der Eycken, Johan
experimental part, p. 6410 - 6415 (2009/12/09)
Catalyst-free alcoholytic deprotection of borane-protected phosphorus compounds offers a smooth, efficient, and clean alternative to existing deprotection methods. In this paper we report our results on the general applicability of deprotecting phosphane-
