5519-03-9

Basic information

• Product Name: BOC-GLY-PHE-OBZL
• Synonyms: BOC-GLY-PHE-OBZL
• CAS NO: 5519-03-9
• Molecular Formula: C₂₃H₂₈N₂O₅
• Molecular Weight: 412.48
• Mol File: 5519-03-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 78-80 °C
• Boiling Point: 603.4±55.0 °C(Predicted)
• Appearance: /
• Density: 1.166±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 11.23±0.46(Predicted)
• CAS DataBase Reference: BOC-GLY-PHE-OBZL(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-GLY-PHE-OBZL(5519-03-9)
• EPA Substance Registry System: BOC-GLY-PHE-OBZL(5519-03-9)

Safety Data

• Hazardous Substances Data: 5519-03-9(Hazardous Substances Data)

Upstream product

• 2016-04-8 N,N-dimethylformamide dibenzyl acetal 
• 4530-37-4 N-t-butyloxycarbonylglycyl-L-phenylalanine 
• 1738-78-9 L-phenylalanine benzyl ester p-toluene-sulfonic acid salt 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 4530-20-5 BOC-glycine 
• 2462-32-0 L-phenylalanine benzyl ester hydrochloride 
• 100-51-6 benzyl alcohol 
• 962-39-0 L-Phenylalanine benzyl ester 

Downstream Products

• 98297-87-1 Boc-Gly-Phe-Met-Arg(Mts)-OH 
• 84143-88-4 Boc-Gly-Phe-NHNH₂ 
• 97642-06-3 Z-Arg(NO₂)-Pro-Gly-Phe-OBzl 
• 98297-81-5 Boc-Gly-Phe-Leu-Arg(NO₂)-OBzl 
• 53459-50-0 NH₂-Gly-Phe-OBn 

Relevant articles and documents

METHOD FOR PRODUCING CARBOXYLIC ACID AMIDE COMPOUND, AND CATALYST AND FLOW PRODUCTION SYSTEM

PROBLEM TO BE SOLVED: To provide a new production method that allows a dehydration condensation reaction between carboxylic acid and amine, and a catalyst. SOLUTION: A method for producing a carboxylic acid amide compound includes the step for causing a r

N-Primary-amine tetrapeptide-catalyzed highly asymmetric Michael addition of aliphatic aldehydes to maleimides

The highly asymmetric Michael addition reaction between maleimides and aliphatic aldehydes catalyzed by low-loading β-turn tetrapeptides with excellent yields and enantioselectivities at room temperature was reported. α-Branched and α-unbranched aldehydes both are suitable nucleophiles. N-Aryl, alkyl and hydrogen maleimides all are well tolerated and led to high yields and enantioselectivities. The transformation can be enlarged to the gram scale without decrease in the yield and enantioselectivity. Furthermore, the succinimides were converted into γ-lactams and γ-lactones, showing good practicality of this work. Some reaction intermediates in the proposed reaction mechanism can be captured with the HR-MS method.

Synthesis of N,N′-carbonyl-bis-amino acids and N,N′-carbonyl-bis-peptides

A new method for the preparation of N,N′-carbonyl-bis-amino acid esters by reaction of bis(4-nitrophenyl)carbonate with amino acid esters is described. When the carbonate reacts with two equivalents of a peptide ester, N,N′-carbonyl-bis(peptide ester) is obtained but, a hydantoin derivative is formed as a side product. The hydantoin derivative is a major product, when equimolar amounts are allowed to react. Usefulness of this method for preparation of larger N,N′carbonyl-bis-peptides is demonstrated by the synthesis of the respective product from C-terminal hexapeptide of Substance P linked to the Merrifield resin.