551944-18-4

Basic information

• Product Name: (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid
• Synonyms: (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid
• CAS NO: 551944-18-4
• Molecular Weight: 364.485
• Mol File: 551944-18-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid(551944-18-4)
• EPA Substance Registry System: (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid(551944-18-4)

Safety Data

• Hazardous Substances Data: 551944-18-4(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 5947-49-9 podocarpic acid 
• 4614-56-6 methyl podocarpate 
• 55025-16-6 methyl (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate 
• 858519-33-2 (1S,4aS,10aR)-6-Benzyloxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid methoxymethyl ester 
• 858519-32-1 (1S,4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid methoxymethyl ester 

Downstream Products

• 551944-34-4 (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carbonyl chloride 
• 551944-27-5 C₄₈H₅₄O₅ 
• 551944-28-6 (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxamide 
• 551944-26-4 (4β,5α)-12-(Benzyloxy)podocarpa-8,11,13-trien-16-yl (4β,5α)-12-(benzyloxy)podocarpa-8,11,13-trien-16-oate 
• 551944-35-5 1,3-Bis-((1S,4aS,10aR)-6-benzyloxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-propane-1,3-dione 
• 551944-29-7 (1S,4aS,10aR)-6-(benzyloxy)-N-((1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carbonyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxamide 
• 551943-96-5 (4β,5α)-12-Hydroxy-N-[(1-phenylcyclobutyl)methyl]podocarpa-8,11,13-trien-16-amide 
• 551944-24-2 (4β,5α)-12-(Benzyloxy)-N-{[1-(3-methoxyphenyl)cyclohexyl]methyl}podocarpa-8,11,13-trien-16-amide 

Relevant articles and documents

ANTI-MSR1 ANTIBODIES AND METHODS OF USE THEREOF

Provided herein are antibodies and antigen-binding fragments that bind MSR1 and methods of use thereof. According to certain embodiments, the antibodies bind human MSR1 with high affinity. In certain embodiments, the antibodies bind MSR1 without blocking, or blocking less than 90%, of modified LDL binding to MSR1. In some embodiments, the antibodies bind cell surface expressed-MSR1 and are internalized. The antibodies of the invention may be fully human antibodies. The invention includes anti-MSR1 antibodies, or antigen-binding fragments thereof, conjugated to drugs or therapeutic compounds.

BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDES AND PROTEIN CONJUGATES THEREOF

Provided herein are compounds, compositions and methods for the treatment of diseases and disorders associated with the liver X receptor, including bis-octahydrophenanthrene carboxamides and protein (e.g., antibody) drug conjugates thereof.

Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis

A series of podocarpic acid amides were identified as potent agonists for Liver X receptor α and β subtypes, which are members of a nuclear hormone receptor superfamily that are involved in the regulation of a variety of metabolic pathways including chole