551944-31-1Relevant articles and documents
Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters
Singh, Sheo B.,Ondeyka, John G.,Liu, Weiguo,Chen, Steve,Chen, Tom S.,Li, Xiaohua,Bouffard, Aileen,Dropinski, James,Jones, A. Brian,McCormick, Sherrie,Hayes, Nancy,Wang, Jianhua,Sharma, Neelam,MacNaul, Karen,Hernandez, Melba,Chao, Yu-Sheng,Baffic, Joanne,Lam, My-Hanh,Burton, Charlotte,Sparrow, Carl P.,Menke, John G.
, p. 2824 - 2828 (2007/10/03)
Liver X receptors are nuclear receptors that regulate metabolism of cholesterol. They are activated by oxysterols resulting in increased transcription of the ABCA1 gene, promoting cholesterol efflux and HDL formation. We have identified podocarpic acid an
