5522-73-6

Basic information

• Product Name: methyl (17S,18S)-12-ethenyl-7-ethyl-18-(3-methoxy-3-oxopropyl)-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-2-carboxylate
• Synonyms: (7S,8S)-13-Ethenyl-18-ethyl-7,8-dihydro-3-(methoxycarbonyl)-2,8,12,17-tetramethyl-21H,23H-porphine-7-propanoic Acid Methyl Ester; 5522-73-6; Chlorine f Dimethyl Ester; Rhodochlorin XV Dimethyl Ester; Rhodochlorine Dimethyl Ester
• CAS NO: 5522-73-6
• Molecular Formula: C₃₄H₃₈N₄O₄
• Molecular Weight: 566.6899
• Mol File: 5522-73-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 898.556°C at 760 mmHg
• Flash Point: 497.229°C
• Density: 1.181g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: methyl (17S,18S)-12-ethenyl-7-ethyl-18-(3-methoxy-3-oxopropyl)-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (17S,18S)-12-ethenyl-7-ethyl-18-(3-methoxy-3-oxopropyl)-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-2-carboxylate(5522-73-6)
• EPA Substance Registry System: methyl (17S,18S)-12-ethenyl-7-ethyl-18-(3-methoxy-3-oxopropyl)-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-2-carboxylate(5522-73-6)

Safety Data

• Hazardous Substances Data: 5522-73-6(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 77-78-1 dimethyl sulfate 
• 5594-30-9 pheophorbide a methyl ester 
• 15664-29-6 pheophorbide a 

Relevant articles and documents

Novel dual-mode antitumor chlorin-based derivatives as potent photosensitizers and histone deacetylase inhibitors for photodynamic therapy and chemotherapy

The combination of photodynamic therapy (PDT) and chemotherapy is a prospective strategy to improve antitumor efficacy. Herein, a series of novel cytotoxic chlorin-based derivatives as dual photosensitizers (PSs) and histone deacetylase inhibitors (HDACIs) were synthesized and investigated for biological activity. Among them, compound 15e showed definite HDAC2 and 10 inhibitory activities by up-regulating expression of acetyl-H4 and highest phototoxicity and dark-toxicity, which was more phototoxic than Talaporfin as a PS while with stronger dark-toxicity compared to vorinostat (SAHA) as a HDACI. The biological assays demonstrated that 15e was liable to enter A549 cells and localized in mitochondria, lysosomes, golgi and endoplasmic reticulum (ER) etc. multiple organelles, resulting in higher cell apoptosis rate and ROS production compared to Talaporfin. Moreover, it could induce tumor cell autophagy as a dual PS and HDACI. All results suggested that compound 15e could be applied as a potential dual cytotoxic drug for PDT and chemotherapy.

Raney Nickel Reductions of Chlorophyll Derivatives: Hydroporphyrins in the Anhydro Series

Raney nickel reductions of nickel(II) anhydromesorhodoporphyrin XV (17) provide a series of readily separable nickel(II) hydroporphyrins.Apart from the two expected isobacteriochlorins 19 and 22, two hexahydroporphyrins 20 and 21 were obtained as the major reduction product (32percent).Hexahydroporphyrins of the pyrrocorphin type (7) observed in Raney nickel reductions of pheophorbides were not observed.The most novel hydroporphyrin isolated was an octahydroporphyrin 23 obtained in 5percent yield by further reduction of the hexahydroporphyrin isomers.