552331-05-2

Basic information

• Product Name: 6-Bromo-1,3-dichloroisoquinoline
• Synonyms: Isoquinoline, 6-broMo-1,3-dichloro-;1,3-Dichloro-6-broMoisoquinoline;6-Bromo-1,3-dichloro-2-azanaphthalene;6-Bromo-1,3-dichloroisoquinoline96%;6-Bromo-1,3-dichloroisoquinoline;6-Bromo-1,3-dichloroisoquinoline 96%
• CAS NO: 552331-05-2
• Molecular Formula: C₉H₄BrCl₂N
• Molecular Weight: 276.94476
• Product Categories: Halogenated Heterocycles;Heterocyclic Building Blocks;blocks;Bromides;Heterocycles;Quinolines;Quinoline&Isoquinoline;IsoquinolinesBuilding Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Isoquinolines;Building Blocks;Chemical Synthesis
• Mol File: 552331-05-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 124-128°C
• Boiling Point: 383.379 °C at 760 mmHg
• Flash Point: 185.661 °C
• Appearance: /
• Density: 1.766 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.686
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -2.05±0.50(Predicted)
• CAS DataBase Reference: 6-Bromo-1,3-dichloroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-1,3-dichloroisoquinoline(552331-05-2)
• EPA Substance Registry System: 6-Bromo-1,3-dichloroisoquinoline(552331-05-2)

Safety Data

• Hazard Codes: T
• Statements: 25-37/38-41
• Safety Statements: 26-39-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 552331-05-2(Hazardous Substances Data)

Usage

General Description

6-Bromo-1,3-dichloroisoquinoline is a chemical compound with a molecular formula C9H4BrCl2N. It is a heterocyclic organic compound that contains both bromine and chlorine atoms. 6-Bromo-1,3-dichloroisoquinoline is often used in the field of organic chemistry as a building block for the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological and pharmacological activities. 6-Bromo-1,3-dichloroisoquinoline can be synthesized through various methods, including the reaction between 1,3-dichloroisoquinoline and a brominating agent. Its structure and properties make it a versatile and important intermediate in the production of diverse chemical compounds.

InChI:InChI=1/C9H4BrCl2N/c10-6-1-2-7-5(3-6)4-8(11)13-9(7)12/h1-4H

Upstream product

• 552331-04-1 6-bromo-indan-1,2-dione 1-oxime 
• 501130-49-0 6-bromoisoquinoline-1,3(2H,4H)-dione 
• 943749-63-1 4-bromo-2-(carboxymethyl)benzoic acid 

Downstream Products

• 552331-06-3 6-bromo-3-chloro-isoquinoline 

Relevant articles and documents

Synthesis of medical intermediate disubstituted N-containing heterocycle amine compound

The invention relates to synthesis of a medical intermediate disubstituted N-containing heterocycle amine compound. The synthesis comprises the following steps: reacting 5-bromo-2-carboxy-phenylaceticacid, urea and o-dichlorobenzene as raw materials to obtain 6-bromoisoquinoline-1, 3 (2H,4H)-dione; allowing the 6-bromoisoquinoline-1, 3 (2H,4H)-dione to react with phenyl dichloro sphosphineoxide,adding tetrahydrofuran to precipitate out, adjusting the pH value, and then passing through a column to obtain 1, 3-dichloro-6-bromoisoquinoline; then adding glacial acetic acid, red phosphorus and hydroiodic acid, and after the reaction, determining whether the reaction is complete or not by TLC, subjecting the filtrate and the filter cake to repeated fine treatment to obtain 3-chloro-6-bromoisoquinoline; adding copper sulfate pentahydrate, 6-bromo-3-chloroisoquinoline and a large amount of 15% ammonia water to react in a high-pressure kettle, extracting and passing column for many times according to different requirements to obtain the final product 3-chloro-6-aminoisoquinoline.

Kinase inhibitors

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.