552331-75-6 Usage
Description
[5-(4-methoxy-benzyloxy)-pyridin-3-yl]-carbamic acid tert-butyl ester, also known as TAK-875, is a chemical compound that functions as a potent and selective agonist of the G protein-coupled receptor GPR40. This receptor plays a crucial role in the regulation of insulin secretion by pancreatic beta cells. TAK-875 is characterized by its ability to enhance glucose-stimulated insulin secretion and improve glycemic control, making it a promising pharmaceutical candidate for the treatment of type 2 diabetes mellitus.
Uses
Used in Pharmaceutical Industry:
TAK-875 is used as a potential treatment for type 2 diabetes mellitus due to its ability to enhance glucose-stimulated insulin secretion and improve glycemic control. It has shown promising results in clinical trials, with its efficacy and safety profile making it a potential alternative to existing diabetes medications.
Used in Clinical Research:
TAK-875 is utilized in clinical trials to evaluate its potential as a treatment for type 2 diabetes mellitus. These trials aim to assess the compound's efficacy, safety, and long-term effects, as well as to understand its mechanisms of action in regulating insulin secretion and glycemic control.
Used in Drug Development:
TAK-875 serves as a key compound in the development of new drugs for the treatment of type 2 diabetes mellitus. Its potent and selective agonist properties make it a valuable starting point for the design and synthesis of novel therapeutic agents that target the GPR40 receptor and improve insulin secretion and glycemic control.
Further research is needed to fully understand the mechanisms of action and long-term effects of TAK-875, as well as to explore its potential applications in other areas of medicine and healthcare.
Check Digit Verification of cas no
The CAS Registry Mumber 552331-75-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,5,2,3,3 and 1 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 552331-75:
(8*5)+(7*5)+(6*2)+(5*3)+(4*3)+(3*1)+(2*7)+(1*5)=136
136 % 10 = 6
So 552331-75-6 is a valid CAS Registry Number.
552331-75-6Relevant articles and documents
Synthesis and structure-activity relationship of 3,4′- bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer
Li, Qun,Woods, Keith W.,Thomas, Sheela,Zhu, Gui-Dong,Packard, Garrick,Fisher, John,Li, Tongmei,Gong, Jianchun,Dinges, Jurgen,Song, Xiaohong,Abrams, Jason,Luo, Yan,Johnson, Eric F.,Shi, Yan,Liu, Xuesong,Klinghofer, Vered,Des Jong, Ron,Oltersdorf, Tilman,Stoll, Vincent S.,Jakob, Clarissa G.,Rosenberg, Saul H.,Giranda, Vincent L.
, p. 2000 - 2007 (2007/10/03)
Structure-based design and synthesis of the 3,4′-bispyridinylethylene series led to the discovery of 3-isoquinolinylpyridine 13a as a potent PKB/Akt inhibitor with an IC50 of 1.3 nM against Akt1. Compound 13a shows excellent selectivity against distinct families of kinases such as tyrosine kinases and CAMK, and displays poor to marginal selectivity against closely related kinases in the AGC and CMGC families. Moreover, 13a demonstrates potent cellular activity comparable to staurosporine, with IC50 values of 0.42 and 0.59 μM against MiaPaCa-2 and the Akt1 overexpressing FL5.12-Akt1, respectively. Inhibition of phosphorylation of the Akt downstream target GSK3 was also observed in FL5.12-Akt1 cells with an EC50 of 1.5 μM. The X-ray structures of 12 and 13a in complex with PKA in the ATP-binding site were determined.
Kinase inhibitors
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, (2008/06/13)
Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
