552333-01-4

Basic information

• Product Name: 2-(2-amino-4-bromo-phenyl)-malonic acid di-tert-butyl ester
• Synonyms: 2-(2-amino-4-bromo-phenyl)-malonic acid di-tert-butyl ester
• CAS NO: 552333-01-4
• Molecular Weight: 386.286
• Mol File: 552333-01-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2-amino-4-bromo-phenyl)-malonic acid di-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-amino-4-bromo-phenyl)-malonic acid di-tert-butyl ester(552333-01-4)
• EPA Substance Registry System: 2-(2-amino-4-bromo-phenyl)-malonic acid di-tert-butyl ester(552333-01-4)

Safety Data

• Hazardous Substances Data: 552333-01-4(Hazardous Substances Data)

Upstream product

• 3460-18-2 1,4-dibromo-2-nitrobenzene 
• 541-16-2 t-butyl malonate 
• 7440-06-4 platinum 

Downstream Products

• 552333-19-4 2-{2-[(Adamantan-1-ylmethyl)-amino]4-bromo-phenyl}-malonic acid di-tert-butyl ester 

Relevant articles and documents

SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C

This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid(benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

3,3-disubstituted-oxindole derivatives useful as anticancer agents

The present invention relates to compounds of formula 1 and to pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein n is 0 or 1 and R1, R2, R3, R4, and R5are as defined herein. The above compounds of formula 1 are useful in the treatment of hyperproliferative disorders, such as cancer, in mammals. The invention also relates to pharmaceutical compositions containing the compounds of formula 1, to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering the compounds of formula 1 to a mammal requiring such treatment, and to methods of preparing compounds of formula 1.