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5526-38-5

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5526-38-5 Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 31, p. 1032, 1966 DOI: 10.1021/jo01342a010

Check Digit Verification of cas no

The CAS Registry Mumber 5526-38-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,5,2 and 6 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5526-38:
(6*5)+(5*5)+(4*2)+(3*6)+(2*3)+(1*8)=95
95 % 10 = 5
So 5526-38-5 is a valid CAS Registry Number.

5526-38-5Relevant articles and documents

The Botrytis cinerea type III polyketide synthase shows unprecedented high catalytic efficiency toward long chain acyl-CoAs

Jeya, Marimuthu,Kim, Tae-Su,Tiwari, Manish Kumar,Li, Jinglin,Lee, Jung-Kul,Zhao, Huimin

, p. 2864 - 2867,4 (2012)

BPKS from Botrytis cinerea is a novel type III polyketide synthase that accepts C4-C18 aliphatic acyl-CoAs and benzoyl-CoA as the starters to form pyrones, resorcylic acids and resorcinols through sequential condensation with malonyl-CoA. The catalytic efficiency (kcat/K m) of BPKS was 2.8 × 105 s-1 M -1 for palmitoyl-CoA, the highest ever reported. Substrate docking analyses addressed the unique features of BPKS such as its high activity and high specificity toward long chain acyl-CoAs.

Nonpeptidic potent HIV-1 protease inhibitors: (4-hydroxy-6-phenyl-2-oxo- 2H-pyran-3-yl)thiomethanes that span P1-P2' subsites in a unique mode of active site binding

Prasad,Para,Tummino,Ferguson,McQuade,Lunney,Rapundalo,Batley,Hingorani,Domagala,Gracheck,Bhat,Liu,Baldwin,Erickson,Sawyer

, p. 898 - 905 (1995)

Using molecular modeling and the information derived from the X-ray crystal structure of HIV-1 protease (HIV PR) complexed with the pyran-2-one l, a series of (4-hydroxy-6-phenyl-2-oxo-2H-pyran-3-yl)thiomethanes was designed and analyzed as novel, nonpept

Synthesis and antimicrobial activity of new prenylated 2-pyrone derivatives

Chukwujekwu, Jude C.,Obi, Grace,van Heerden, Fanie R.

, (2020/02/11)

A series of new monoprenylated and diprenylated 2-pyrone derivatives with different halogen substituents were synthesized from the corresponding 6-aryl-4-hydroxy-2-pyrones by prenylation reactions. The compounds were evaluated for antibacterial activity and displayed significant in vitro activity with the highest activity shown by the monoprenylated 6-aryl-2-pyrones. All the compounds except the bromine-containing analogs were active against one or more tested bacteria, with Escherichia coli being the most susceptible of the test organisms. With the remarkable antibacterial activity of eight of the compounds against a drug-resistant β-lactamase-producing Klebsiella pneumoniae, a synergistic evaluation between each of these compounds and ampicillin was undertaken. Out of the eight combinations studied, synergistic effects were observed with two compounds, 4-(3-methylbut-2-enoxy)-6-phenyl-2H-pyran-2-one and 6-(4-fluorophenyl)-4-(3-methylbut-2-enoxy)-2H-pyran-2-one. Both compounds, at half the individual MIC values, were able to lower the MIC of ampicillin in combinations from 2500 to 2.4 μg/mL (1/1041 of MIC).

NEW ANTIBACTERIAL COMPOUNDS

-

Page/Page column 43-44, (2016/07/05)

The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.

Cloning and structure-function analyses of quinolone- and acridone-producing novel type III polyketide synthases from citrus microcarpa

Mori, Takahiro,Shimokawa, Yoshihiko,Matsui, Takashi,Kinjo, Keishi,Kato, Ryohei,Noguchi, Hiroshi,Sugio, Shigetoshi,Morita, Hiroyuki,Abe, Ikuro

, p. 28845 - 28858 (2013/10/22)

Background:Type III polyketide synthases (PKSs) synthesize various polyketide and alkaloid scaffolds. Results:QNS synthesizes quinolone as the single product, whereas ACS produces acridone as the major product. Conclusion:QNS and ACS are novel quinolone- and acridone-producing type III PKSs, respectively. Significance:Structure-function analyses of QNS and ACS provide insights into molecular bases for alkaloid biosyntheses.

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