55270-04-7 Usage
Description
(CIS-1-AMINO-INDAN-2-YL)-METHANOL, with the molecular formula C10H13NO, is a chemical compound derived from indan, featuring a bicyclic structure. This methanol derivative has an amino group attached to the carbon atom in the cis position of the indan ring. It is a versatile compound used in various applications, including research and development, pharmaceuticals, and agrochemicals, due to its unique structure and potential biological activity.
Uses
Used in Research and Development:
(CIS-1-AMINO-INDAN-2-YL)-METHANOL is used as a building block for the synthesis of other organic compounds, contributing to the advancement of chemical research and the development of novel materials.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (CIS-1-AMINO-INDAN-2-YL)-METHANOL is used as a key intermediate in the development of new drugs, leveraging its unique structure and potential biological activity for therapeutic applications.
Used in Agrochemical Industry:
(CIS-1-AMINO-INDAN-2-YL)-METHANOL is also utilized in the agrochemical industry, where it serves as a starting material for the synthesis of various agrochemical products, such as pesticides and fertilizers, due to its potential biological activity and chemical properties.
Used in Organic Synthesis Processes:
As a reagent in organic synthesis processes, (CIS-1-AMINO-INDAN-2-YL)-METHANOL is employed to facilitate the creation of new compounds and materials, further expanding its applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 55270-04-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,2,7 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 55270-04:
(7*5)+(6*5)+(5*2)+(4*7)+(3*0)+(2*0)+(1*4)=107
107 % 10 = 7
So 55270-04-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO/c11-10-8(6-12)5-7-3-1-2-4-9(7)10/h1-4,8,10,12H,5-6,11H2/t8-,10+/m0/s1
55270-04-7Relevant articles and documents
Structure-based design and synthesis of an HIV-1 entry inhibitor exploiting X-ray and thermodynamic characterization
LaLonde, Judith M.,Le-Khac, Matthew,Jones, David M.,Courter, Joel R.,Park, Jongwoo,Schoen, Arne,Princiotto, Amy M.,Wu, Xueling,Mascola, John R.,Freire, Ernesto,Sodroski, Joseph,Madani, Navid,Hendrickson, Wayne A.,Smith, Amos B.
supporting information, p. 338 - 343 (2013/05/08)
The design, synthesis, thermodynamic and crystallographic characterization of a potent, broad spectrum, second-generation HIV-1 entry inhibitor that engages conserved carbonyl hydrogen bonds within gp120 has been achieved. The optimized antagonist exhibits a submicromolar binding affinity (110 nM) and inhibits viral entry of clade B and C viruses (IC50 geometric mean titer of 1.7 and 14.0 μM, respectively), without promoting CD4-independent viral entry. The thermodynamic signatures indicate a binding preference for the (R,R)- over the (S,S)-enantiomer. The crystal structure of the small-molecule/gp120 complex reveals the displacement of crystallographic water and the formation of a hydrogen bond with a backbone carbonyl of the bridging sheet. Thus, structure-based design and synthesis targeting the highly conserved and structurally characterized CD4-gp120 interface is an effective tactic to enhance the neutralization potency of small-molecule HIV-1 entry inhibitors.
