552856-52-7Relevant articles and documents
Synthesis of 2′-amino-LNA: A new strategy
Rosenbohm, Christoph,Christensen, Signe M.,Sorensen, Mads D.,Pedersen, Daniel Sejer,Larsen, Lotte-Emilie,Wengel, Jesper,Koch, Troels
, p. 655 - 663 (2007/10/03)
In this paper we present revised and significantly improved synthetic routes to 2′-amino-LNA (locked nucleic acid). The optimal route is convergent with the synthesis of LNA monomers ("2′-oxy-LNA") via a common intermediate obtained by a mild deacetylatio