553-27-5Relevant articles and documents
A squaraine-based colorimetric and "turn on" fluorescent sensor for selective detection of Hg2+ in an aqueous medium
Chen, Cheng,Wang, Ruyong,Guo, Liangqia,Fu, Nanyan,Dong, Haijun,Yuan, Yaofeng
, p. 1162 - 1165 (2011)
A novel squaraine-based chemosensor SQ-1 has been synthesized, and its sensing behavior toward various metal ions was investigated by UV-vis and fluorescence spectroscopies. In AcOH-H2O (40:60, v/v) solution, Hg2+ ions coordinate with SQ-1 causing a deaggregation which induces a visual color and absorption spectral changes as well as strong fluorescence. In contrast, the addition of other metals (e.g., Pb2+, Cd 2+, Cu2+, Zn2+, Al3+, Ni 2+, Co2+, Fe3+, Ca2+, K+, Mg2+, Na+, and Ag+) does not induce these changes at all. Thus SQ-1 is a specific Hg2+ sensing agent due to the inducing deaggregation of the dye molecule by Hg2+.(Figure Presented)
Fluorescent probe molecule for detecting azo reductase based on coumarin derivative as well as preparation method and application of fluorescent probe molecule
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, (2021/07/17)
The invention provides a fluorescent probe molecule for detecting azo reductase based on a coumarin derivative as well as a preparation method and application of the fluorescent probe molecule, and belongs to the technical field of protease detection reagents. The fluorescent probe molecule prepared by the invention can provide a molecule combined with a specific biological enzyme-azo reductase, so that azo groups in a probe structure are reduced by the azo reductase, a fluorophore coumarin derivative is released, fluorescence of the probe molecule is changed, and an anticancer active drug phenylalanine mustard is released at the same time; therefore, the azo reductase in a liquid phase system is selectively identified and detected. Therefore, the invention provides the application of the fluorescent probe molecule in preparation of a reagent for detecting azo reductase and/or detection of Sn in a water body.
Hypoxia-activatable nano-prodrug for fluorescently tracking drug release in mice
Li, Haidong,Yao, Qichao,Pu, Zhongji,Chung, Jeewon,Ge, Haoying,Shi, Chao,Xu, Ning,Xu, Feng,Sun, Wen,Du, Jianjun,Fan, Jiangli,Wang, Jingyun,Yoon, Juyoung,Peng, Xiaojun
, p. 499 - 508 (2021/01/25)
Chemotherapy is one of the commonly used methods to treat various types of cancers in clinic by virtue of its high efficiency and universality. However, strong side effects and low concentration of conventional drugs at the tumor site have always been important factors that plague the chemotherapy effects of patients, further precluding their practical applications. Thereof, to solve the above dilemma, by integration of anticancer drug (nitrogen mustard, NM) into an NIR fluorophore (a dicyanoisophorone derivative), an intelligent prodrug NIR-NM was developed via molecular engineering strategy. Prodrug NIR-NM stimulated in hypoxia condition exhibits significantly higher toxicity to cancer cells than normal cells, essentially reducing the collateral damage to healthy cells and tissues of nitrogen mustard. More importantly, the nanoparticle prodrug FA-lip@NIR-NM showed the advantages of the high accumulation of drug at tumor site and long-circulation capacity in vivo, which endowed it the ability to track the release of the active chemotherapeutic drug and further treat solid tumors.[Figure not available: see fulltext.].
Chemoselective detection of Ag+ in purely aqueous solution using fluorescence ‘turn-on’ probe based on crown-containing 4-methoxy-1,8-naphthalimide
Panchenko, Pavel A.,Polyakova, Anna S.,Fedorov, Yurii V.,Fedorova, Olga A.
, p. 155 - 157 (2019/04/25)
A novel derivative of 4-methoxy-1,8-naphthalimide bearing N-phenylazadithia-15-crown-5 ether receptor has been demonstrated as the selective and sensitive fluorescent probe for the detection of silver(I) ions in purely aqueous solution at neutral pH.
