553-60-6

Basic information

• Product Name: ISOPROPYL NICOTINATE
• Synonyms: 3-Pyridinecarboxylic acid, 1-methylethyl ester;3-pyridinecarboxylicacid,1-methylethylester;Nicotinic acid, isopropyl ester;Nipyl;ISOPROPYL NICOTINATE;3-Pyridinecarboxylic acid isopropyl ester;Pyridine-3-carboxylic acid 1-methylethyl ester;Pyridine-3-carboxylic acid isopropyl ester
• CAS NO: 553-60-6
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• EINECS: 209-043-1
• Mol File: 553-60-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 293.03°C (rough estimate)
• Flash Point: 91.1°C
• Appearance: /
• Density: 1.066 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.079mmHg at 25°C
• Refractive Index: 1.4926 (estimate)
• PKA: 3.38±0.10(Predicted)
• CAS DataBase Reference: ISOPROPYL NICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: ISOPROPYL NICOTINATE(553-60-6)
• EPA Substance Registry System: ISOPROPYL NICOTINATE(553-60-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 553-60-6(Hazardous Substances Data)

Usage

General Description

ISOPROPYL NICOTINATE is an organic compound that belongs to the class of nicotinate esters. It is commonly used in the pharmaceutical and cosmetic industries for its vasodilatory properties, meaning it can dilate blood vessels and improve blood circulation. This makes it a popular ingredient in topical creams and gels for the treatment of various skin conditions such as cellulite, stretch marks, and wrinkles. ISOPROPYL NICOTINATE is also known for its potential as a transdermal enhancer, meaning it can help other active ingredients penetrate the skin more effectively. However,

InChI:InChI=1/C9H11NO2/c1-7(2)12-9(11)8-4-3-5-10-6-8/h3-7H,1-2H3

Upstream product

• 59-67-6 nicotinic acid 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 
• 67-63-0 isopropyl alcohol 
• 75-30-9 2-iodo-propane 
• 100-54-9 pyridine-3-carbonitrile 

Downstream Products

• 59-67-6 nicotinic acid 
• 187737-37-7 propene 

Relevant articles and documents

N-alkylation of pyridylalanine and pyridinecarboxylic acids and their use in synthesis of GnRH antagonists

A mild N-alkylation method has been developed for the synthesis of N-alkylated pyridiniumcarboxylic acids, using Ag2O-H2O catalysis to enhance the low-reactivity of pyridinecarboxylic acids. Two approaches were undertaken for the synthesis of a series of GnRH antagonists containing pyridinium moieties at the side chain: (1) incorporation of Npy-alkylated D-pyridylalanine during solid phase peptide chain assembly, and (2) coupling of the N-alkylated pyridinium-carboxylic acid to the resin-bound ε-amino group of a D-lysine on a solid support.

AMIDATION METHOD AND ESTERIFICATION METHOD USING SULFONIC ACID HALIDE

PROBLEM TO BE SOLVED: To provide a safe and economical method for rapidly synthesizing amides and esters in high yield. SOLUTION: There is provided a method for amidating an amine or a derivative thereof using a sulfonic acid halide, where a sulfonic acid halide is allowed to act as an activator on a carboxylic acid or a derivative thereof to synthesize an active ester, and the active ester is reacted with an amine or a derivative thereof as a nucleophile to amidate the amine or the derivative thereof to obtain a corresponding amide or a derivative thereof. In a similar manner, a sulfonic acid halide is allowed to act as an activator on a carboxylic acid or a derivative thereof to synthesize an active ester, and the active ester is reacted with an alcohol or a derivative thereof as a nucleophile to esterify the alcohol or the derivative thereof to obtain a corresponding ester or a derivative thereof. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPO&INPIT