55300-29-3 Usage
Originator
Stakane,Dausse,France,1977
Uses
Immunizing agent (passive).
Manufacturing Process
A mixture of 18.65 g (0.05 mol) of allyl 2-(7'-trifluoromethy-4'-
quinolylamino)benzoate, 16.2 g (0.059 mol) of 2-(4'-mtrifluoromethylphenylpiperazino)
ethanol, 150 ml of anhydrous toluene and
0.03 g of sodium is heated under reflux for 2 ? hours, while the allyl alcohol
formed during the reaction is slowly removed by distillation. A slight amount
of insoluble matter is filtered off and the toluene is evaporated from the
filtrate. The residue is dissolved in a mixture of methylene chloride and
acetone (8:2) and this solution is passed through a silica column. Elution is
carried out with the same mixture of solvents and the eluate is collected in 50ml fractions. These fractions are examined by thin layer chromatography.
Those which contain the desired almost pure ester are combined and the
solvent is driven off from them. The residual product is triturated in a mixture
of ether and petroleum ether, filtered off and dried. 16.8 g (yield 57%) of 2-
(4'-m-trifluoromethylphenylpiperazino)ethyl 2-(7'-trifluoromethyl-4'-
quinolylamino)benzoate, melting point 88° to 90°C, are thus isolated.
Therapeutic Function
Analgesic
Check Digit Verification of cas no
The CAS Registry Mumber 55300-29-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,3,0 and 0 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 55300-29:
(7*5)+(6*5)+(5*3)+(4*0)+(3*0)+(2*2)+(1*9)=93
93 % 10 = 3
So 55300-29-3 is a valid CAS Registry Number.
InChI:InChI=1/C30H26F6N4O2/c31-29(32,33)20-4-3-5-22(18-20)40-14-12-39(13-15-40)16-17-42-28(41)24-6-1-2-7-25(24)38-26-10-11-37-27-19-21(30(34,35)36)8-9-23(26)27/h1-11,18-19H,12-17H2,(H,37,38)
55300-29-3Relevant articles and documents
Iron-Mediated Electrophilic Amination of Organozinc Halides using Organic Azides
Gra?l, Simon,Singer, Johannes,Knochel, Paul
, p. 335 - 338 (2019/11/22)
A wide range of alkyl-, aryl- and heteroarylzinc halides were aminated with highly functionalized alkyl, aryl, and heterocyclic azides. The reaction proceeds smoothly at 50 °C within 1 h in the presence of FeCl3 (0.5 equiv) to furnish the corresponding secondary amines in good yields. This method was extended to peptidic azides and provided the arylated substrates with full retention of configuration. To demonstrate the utility of this reaction, we prepared two amine derivatives of pharmaceutical relevance using this iron-mediated electrophilic amination as the key step.
