55305-86-7

Basic information

• Product Name: Acetic acid, cyclohexylidenefluoro-, ethyl ester
• CAS NO: 55305-86-7
• Molecular Formula: C10H15FO2
• Molecular Weight: 186.226
• Mol File: 55305-86-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Acetic acid, cyclohexylidenefluoro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, cyclohexylidenefluoro-, ethyl ester(55305-86-7)
• EPA Substance Registry System: Acetic acid, cyclohexylidenefluoro-, ethyl ester(55305-86-7)

Safety Data

• Hazardous Substances Data: 55305-86-7(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 55305-80-1 Cyclohexylidene-fluoro-acetyl fluoride 
• 27262-60-8 1-hydroxy-1-ethoxycarbonyl-diazomethylcyclohexane 
• 71-43-2 benzene 
• 2356-16-3 ethyl(diethylphosphono)(fluoro)acetate 
• 108-94-1 cyclohexanone 
• 864363-38-2 fluoro-(1-hydroxy-cyclohexyl)-phenylselanyl-acetic acid ethyl ester 
• 565-53-7 ethyl dibromofluoroacetate 
• 702-56-7 1-(trifluoro vinyl) cyclohexanol 
• 910803-66-6 ethyl α-(1,3-benzothiazol-2-ylsulfonyl)-α-fluoroacetate 

Downstream Products

• 700-62-9 acide cyclohexylidene-2 fluoro-2 acetique 
• 777946-41-5 4-(2-cyclohexylidene-2-fluoro-acetylamino)-piperidine-1-carboxylic acid benzyl ester 
• 1014407-15-8 4-(2-cyclohexylidene-2-fluoro-ethylamino)-piperidine-1-carboxylic acid benzyl ester 
• 777946-40-4 N-(1-benzyl-piperidin-4-yl)-2-cyclohexylidene-2-fluoro-acetamide 
• 777946-31-3 N-adamantan-1-yl-2-cyclohexylidene-2-fluoro-acetamide 
• 777946-37-9 2-cyclohexylidene-2-fluoro-N-(3-trifluoromethyl-benzyl)-acetamide 
• 777946-35-7 N-benzo[1,3]dioxol-5-ylmethyl-2-cyclohexylidene-2-fluoro-acetamide 
• 777946-34-6 2-cyclohexylidene-2-fluoro-N-(4-methoxy-benzyl)-acetamide 
• 777946-30-2 N-cyclohexyl-2-cyclohexylidene-2-fluoro-acetamide 
• 777946-36-8 2-cyclohexylidene-2-fluoro-N-(4-fluoro-benzyl)-acetamide 
• 777946-38-0 2-cyclohexylidene-2-fluoro-N-phenethyl-acetamide 
• 777946-42-6 2-cyclohexylidene-N-(3-dimethylamino-propyl)-2-fluoro-acetamide 
• 777946-33-5 N-benzyl-2-cyclohexylidene-2-fluoro-acetamide 

Relevant articles and documents

P[N(i-Bu)CH2CH2]3N: Nonionic Lewis base for promoting the room-temperature synthesis of α,β-unsaturated esters, fluorides, ketones, and nitriles using Wadsworth - Emmons phosphonates

The bicyclic triaminophosphine P(RNCH2CH2) 3N (R = i-Bu, 1c) serves as an effective promoter for the room-temperature stereoselective synthesis of α,β-unsaturated esters, fluorides, and nitriles from a wide array of aromatic, aliphatic, heterocyclic, and cyclic aldehydes and ketones, using a range of Wadsworth-Emmons (WE) phosphonates. Among the analogues of 1c [R = Me (1a), i-Pr (1b), Bn (1d)], 1a and 1b performed well, although longer reaction times were involved, and 1d led to poorer yields than 1c. Functionalities such as cyano, chloro, bromo, methoxy, amino, ester, and nitro were well tolerated. We were able to isolate and characterize (by X-ray means; see above) the reactive WE intermediate species formed from 2b and 1c.

Phosphonium supported triphenylphosphine reagent: an improved access to α-fluoro-α,β-unsaturated esters

α-Fluoro-α,β-unsaturated esters 2 were efficiently synthetized via diethylzinc-promoted Wittig reaction using a phosphonium-supported triphenylphosphine SCG-PPh3 1, which possesses similar reactivity as its parent analog triphenylphosphine. The

Z-selective or stereospecific alkenylation reaction: A novel synthetic method for α-fluoro-α,β-unsaturated esters

The Z-selective formation of α-fluoro-α,β-unsaturated esters was achieved using the deselenenic acid of the syn-and/or anti-3-aryl-2-fluoro-3-hydroxy-2-organoselanylacetates 3 and 4 with trifluoromethanesulfonic acid. In contrast, the 3-alkyl-substituted propanoates 3f and 4b stereospecifically underwent alkenylation to give the (E)- or (Z)-α-fluoro-α,β-unstaurated esters 5f. We were also successful in the one-pot alkenylation reactions. Copyright