5531-33-9

Basic information

• Product Name: N-(1,1-DiMethyl-2-phenylethyl)acetaMid
• Synonyms: N-(1,1-DiMethyl-2-phenylethyl)acetaMid;N-(2-Methyl-1-phenylpropan-2-yl)acetaMide;AcetaMide, N-(1,1-diMethyl-2-phenylethyl)-
• CAS NO: 5531-33-9
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.26948
• Mol File: 5531-33-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 91.5-92 °C
• Boiling Point: 354.6°Cat760mmHg
• Flash Point: 211.9°C
• Appearance: /
• Density: 0.984g/cm³
• Vapor Pressure: 3.31E-05mmHg at 25°C
• Refractive Index: 1.508
• PKA: 16.47±0.46(Predicted)
• CAS DataBase Reference: N-(1,1-DiMethyl-2-phenylethyl)acetaMid(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1,1-DiMethyl-2-phenylethyl)acetaMid(5531-33-9)
• EPA Substance Registry System: N-(1,1-DiMethyl-2-phenylethyl)acetaMid(5531-33-9)

Safety Data

• Hazardous Substances Data: 5531-33-9(Hazardous Substances Data)

Usage

Uses

N-(2-Methyl-1-phenylpropan-2-yl)acetamide is a byproduct from the preparation of benzolactams by palladium-catalyzed carbonylation of arylethylamines and α-amino benzenepropanoates.

InChI:InChI=1/C12H17NO/c1-10(14)13-12(2,3)9-11-7-5-4-6-8-11/h4-8H,9H2,1-3H3,(H,13,14)

Upstream product

• 100-86-7 2-Methyl-1-phenyl-2-propanol 
• 75-05-8 acetonitrile 
• 6921-34-2 benzylmagnesium chloride 
• 201230-82-2 carbon monoxide 
• 64-19-7 acetic acid 
• 122-09-8 Phentermin 
• 5669-14-7 2,2-dimethyl-3-phenylpropanoic acid 
• 2206-26-0 [D₃]acetonitrile 
• 538-93-2 1-phenyl-2-methylpropane 

Downstream Products

• 55281-79-3 N-chloro-N-(1,1-dimethyl-2-phenyl-ethyl)-acetamide 
• 1197-21-3 phentermine hydrochloride 
• 122-09-8 Phentermin 
• 5531-43-1 N-Aethyl-N-(1,1-dimethyl-phenaethyl)-amin 
• 26307-22-2 N,N'-bis(2-methyl-3-phenyl-2-propyl)diazene 
• 76613-21-3 N,N'-bis(1,1-dimethyl-2-phenylethyl)sulfamide 
• 76613-27-9 N,N'-bis(1,1-dimethyl-2-phenylethyl)thiadiaziridine 1,1-dioxide 
• 55281-81-7 2,4,4-trimethyl-5-phenyl-4,5-dihydro-oxazole 

Relevant articles and documents

Hypervalent Iodine(III)-Mediated Decarboxylative Ritter-Type Amination Leading to the Production of α-Tertiary Amine Derivatives

α-Tertiary amines (ATAs) are attractive structural motifs that are frequently found in biologically active molecules. Therefore, the development of an efficient method for the synthesis of ATAs represents an important research topic in the field of medicinal chemistry as well as organic chemistry. Although the Ritter reaction is a reliable approach for preparing α-tertiary amine derivatives via intermolecular amination reactions, the typical methods suffer from disadvantages such as harsh reaction conditions and the use of strong acids. Because of this, it has been of limited use in the synthesis of ATAs. We report here on the decarboxylative Ritter-type amination of carboxylic acids bearing an α-quaternary carbon center using a combination of PhI(OAc)2 and molecular iodine (I2) to produce the corresponding α-tertiary amine derivatives. This reaction proceeded at ambient temperature on the benchtop with a fluorescent light. Mechanistic investigations suggest that the reaction proceeds via the formation of an alkyl iodide and a higher oxidation state iodine(III) species as key intermediates. Similarly, a stepwise protocol for the Ritter-type amination of alcohols via the formation of oxalic acid monoalkyl esters was also achieved. The present methods represent a useful tool for the synthesis of ATAs that are difficult to prepare by conventional methods.

Magnetic CoFe2O4 nanoparticle immobilized N-propyl diethylenetriamine sulfamic acid as an efficient and recyclable catalyst for the synthesis of amides via the Ritter reaction

A magnetic CoFe2O4 nanoparticle immobilized diamine-N-sulfamic acid (CoFe2O4@SiO2-DASA) was synthesized and used as efficient heterogeneous catalyst for the synthesis of amides via the Ritter reaction under solvent-free conditions. The magnetic nanocatalyst could be readily recovered by applying an external magnet and recycled several times without considerable loss of its catalytic activity.

(ALPHA-SUBSTITUTED ARALKYLAMINO AND HETEROARYLALKYLAMINO) PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN TREATING PROLIFERATIVE DISEASES

Provided herein are (alpha-substituted aralkylamino or heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, e.g., a compound of Formula 1, and their pharmaceutical compositions, preparation, and use as agents or drugs for treating proliferative diseases