55317-02-7

Basic information

• Product Name: 2-METHOXY-1-(2,4,6-TRIHYDROXYPHENYL)ETHANONE
• Synonyms: ALPHA-METHOXYPHLOROACETOPHENONE;2-METHOXY-1-(2,4,6-TRIHYDROXYPHENYL)ETHANONE;A-METHOXYPHLOROACETOPHENONE
• CAS NO: 55317-02-7
• Molecular Formula: C₉H₁₀O₅
• Molecular Weight: 198.17
• Mol File: 55317-02-7.mol
• Article Data: 11

Chemical Properties

• Melting Point: 195–196°C
• Appearance: /
• CAS DataBase Reference: 2-METHOXY-1-(2,4,6-TRIHYDROXYPHENYL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-1-(2,4,6-TRIHYDROXYPHENYL)ETHANONE(55317-02-7)
• EPA Substance Registry System: 2-METHOXY-1-(2,4,6-TRIHYDROXYPHENYL)ETHANONE(55317-02-7)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 55317-02-7(Hazardous Substances Data)

Usage

Preparation

Preparation by reaction of methoxyacetonitrile with phloro-glucinol (Hoesch reaction).

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 1738-36-9 2-methoxyacetonitrile 
• 38870-89-2 Methoxyacetyl chloride 

Downstream Products

• 1486-59-5 4'-(benzyloxy)-5,7-dihydroxy-3-methoxyflavone 
• 1486-61-9 3',4'-bis(benzyloxy)-5,7-dihydroxy-3-methoxyflavone 
• 197245-65-1 5,7-dihydroxy-3-methoxy-2-(3-methoxy-phenyl)-chromen-4-one 
• 852247-39-3 5,7-dihydroxy-3-methoxy-2-(2,4,5-trimethoxy-phenyl)-chromen-4-one 
• 109688-55-3 5,7-dihydroxy-3-methoxy-2-(2,3,4-trimethoxy-phenyl)-chromen-4-one 
• 1592-70-7 3-methoxy-5,7,4'-trihydroxyflavone 
• 62507-01-1 2-(3-benzyloxy-4-methoxy-phenyl)-5,7-dihydroxy-3-methoxy-chromen-4-one 
• 95957-71-4 2-(4-benzyloxy-3-methoxy-phenyl)-5,7-dihydroxy-3-methoxy-chromen-4-one 
• 1486-70-0 2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-methoxy-chromen-4-on 
• 6665-74-3 5,7-dihydroxy-3-methoxyflavone 
• 5150-31-2 5,7-dihydroxy-3-methoxy-3′,4′-methylenedioxyflavone 
• 109337-46-4 2-methoxy-1-(2,4,6-triacetoxy-phenyl)-ethanone 
• 859033-58-2 2-(5,7-dihydroxy-3-methoxy-4-oxo-4H-chromen-2-yl)-benzoic acid 
• 52165-06-7 2-methoxy-1-(2,4,6-tris-benzoyloxy-phenyl)-ethanone 

Relevant articles and documents

2′,4′,6′-trihydroxy-1-methoxyacetophenone monohydrate at 150 K

The geometry of the title compound, 2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone, C9H10O5·H2O, is determined by the presence of an intramolecular hydrogen bond; the geometry of the benzene ring is distorted by a

Myricitrin preparation method

The invention belongs to the technical field of pharmaceutical chemical synthesis, in particular relates to a preparation method of the slots. The invention the equivalent preparation method is as follows: a, in order to 1 - 1 as shown in the compound as a raw material, with the methoxy second grade nitrile under acidic conditions in the acylation reaction to obtain 1 - 3 as shown in the; second, 1 - 3 is shown with the compound 3, 4, 5 - trimethoxy benzoic anhydride generating rearrangement reaction to 1 - 5 as shown in the; three, 1 - 5 shown BBr3 compound in the dichloromethane solution takes place in the demethylation reaction generating 3 - 1 compound of formula, is myricetin. The invention relates to a fully synthetic routes proceed from the phloroglucinol, by the three-step reaction, to 60% of the total yield has succeeded in synthesizing myricetin. With cheap raw material, mild reaction conditions, synthetic route is short, and the yield is high, the operation is simple, and little environmental pollution and the like.

SYNTHESIS OF POLYHYDROXY BENZOPYRAN KETONE COMPOUND AND ANTI-TUMOR EFFECT THEREOF

The present invention is directed to chromenone compounds of formula (I), pharmaceutically acceptable salts, prodrugs thereof, and the composition comprising the compounds or the like. They can be used to modulating the function of estrogen receptor ER-α36 preventing and/or treating the estrogen related diseases, such as breast cancer, leukemia, liver cancer and etc.