55324-06-6

Basic information

• Product Name: 1H-1,2,3-Triazole, 4-methyl-5-phenyl-
• Synonyms: 5-C6H5-1,2,3-Triazol;4-Methyl-5-phenyl-1H-[1,2,3]triazol;1H-1,2,3-Triazole,4-methyl-5-phenyl;4-methyl-5-phenyl-1H-[1,2,3]triazole;4-Methyl-5-phenyl-v-diazol
• CAS NO: 55324-06-6
• Molecular Formula: C9H9N3
• Molecular Weight: 159.191
• Mol File: 55324-06-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-1,2,3-Triazole, 4-methyl-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,3-Triazole, 4-methyl-5-phenyl-(55324-06-6)
• EPA Substance Registry System: 1H-1,2,3-Triazole, 4-methyl-5-phenyl-(55324-06-6)

Safety Data

• Hazardous Substances Data: 55324-06-6(Hazardous Substances Data)

Upstream product

• 93-55-0 1-phenyl-propan-1-one 
• 26386-88-9 diphenyl phosphoryl azide 
• 591-51-5 phenyllithium 
• 107-12-0 propiononitrile 
• 1450-07-3 1-benzoylethylidenetriphenylphosphorane 

Relevant articles and documents

A single-step acid catalyzed reaction for rapid assembly of: NH -1,2,3-triazoles

NH-1,2,3-Triazole moieties are a part of the design of various biologically active compounds, pharmaceutical agents and functional materials. Unfortunately, the applications of this heterocycle are still underexplored due to the lack of a general synthetic protocol. Here we outline a novel, general and facile metal-free pathway that enables the direct synthesis of these heterocycles by combining readily accessible and abundant precursors such as enolizable ketones and NH4OAc with high levels of regioselectivity via an organocascade process. The developed chemistry has been successfully applied to the synthesis of several structurally diverse products, pharmaceutical agents and supramolecular receptors.

SYNTHESIS AND PROPERTIES OF 1,2,3-TRIAZOLES THAT CONTAIN A FERROCENYL RING

Ferrocenesulfonyl azide reacts with a number of aroylmethylenetriphenylphosphinomethylenes in dry methylene chloride to give 1,4,5-trisubstituted 1,2,3-triazoles (61-77percent yields), which are readily converted to 4,5-disubstituted 1,2,3-triazoles and ethyl ferrocenesulfonate when they are refluxed in ethanol.The known triphenylphosphazo ferrocenyl sulfone and ethyl diazoacetate are formed in the case of the reaction of ferrocenesulfonyl azide with carbethoxymethylenetriphenylphosphinomethylene.The structures of the synthesized compounds were proved by the results of elementary analysis and IR, UV, and mass spectroscopy.