5534-12-3

Basic information

• Product Name: [(8S,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl) -10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]p henanthren-17-yl] acetate
• Synonyms: [(8S,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl) -10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]p henanthren-17-yl] acetate
• CAS NO: 5534-12-3
• Molecular Formula: C24H31FO6
• Molecular Weight: 434.4977432
• Mol File: 5534-12-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 569.8°Cat760mmHg
• Flash Point: 298.4°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 2.34E-15mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: [(8S,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl) -10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]p henanthren-17-yl] acetate(CAS DataBase Reference)
• NIST Chemistry Reference: [(8S,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl) -10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]p henanthren-17-yl] acetate(5534-12-3)
• EPA Substance Registry System: [(8S,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl) -10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]p henanthren-17-yl] acetate(5534-12-3)

Safety Data

• Hazardous Substances Data: 5534-12-3(Hazardous Substances Data)

Usage

Description

[(8S,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl) -10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate, also known as flumethasone, is a synthetic corticosteroid hormone derivative. It is characterized by its complex molecular structure with multiple stereocenters and functional groups, which contribute to its potent anti-inflammatory and anti-pruritic properties. Flumethasone's acetate form enhances its solubility and stability in pharmaceutical formulations, making it suitable for various applications.

Uses

Used in Pharmaceutical Industry:
Flumethasone is used as an anti-inflammatory agent for treating various skin conditions, such as eczema, dermatitis, and psoriasis. Its potent anti-inflammatory and anti-pruritic properties help reduce swelling, redness, and itching in the affected area.
Used in Ophthalmic Preparations:
Flumethasone is also used in ophthalmic formulations to treat eye inflammation and allergies. Its ability to inhibit the inflammatory response makes it an effective treatment for conditions like conjunctivitis and uveitis.
Used in Otic Preparations:
In the field of otology, flumethasone is utilized in otic preparations to alleviate inflammation and itching in the ear canal. This application takes advantage of its anti-inflammatory and anti-pruritic properties to provide relief from conditions like otitis externa.
Overall, flumethasone's versatile applications in the pharmaceutical, ophthalmic, and otic industries demonstrate its effectiveness in managing inflammation and itching, making it a valuable asset in the treatment of various conditions.

InChI:InChI=1/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(28)7-8-21(15,3)23(17,25)19(29)11-22(18,4)24(13,20(30)12-26)31-14(2)27/h7-8,10,13,17-19,26,29H,5-6,9,11-12H2,1-4H3/t13-,17-,18-,19-,21-,22-,23?,24-/m0/s1

Upstream product

• 378-44-9 betamethasone 
• 78-39-7 Triethyl orthoacetate 

Relevant articles and documents

Studies on topical antiinflammatory agents. III. Synthesis of 17α-acyloxy-9α-fluoro-11β-hydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 21-thio derivatives and related compounds

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