55377-22-5

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-5-phenyl-
• CAS NO: 55377-22-5
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.239
• Mol File: 55377-22-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-5-phenyl-(55377-22-5)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-5-phenyl-(55377-22-5)

Safety Data

• Hazardous Substances Data: 55377-22-5(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 40738-83-8 5-iodo-1,3-dimethyluracil 
• 62-53-3 aniline 
• 874-14-6 1,3-dimethyluracil 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 71-43-2 benzene 
• 108-86-1 bromobenzene 
• 101-97-3 Ethyl 2-phenylethanoate 
• 116659-61-1 5-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 31217-00-2 5-chloro-1,3-dimethyluracil 
• 7033-39-8 5-bromo-1,3-dimethyluracil 
• 15761-83-8 5-phenyluracil 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 55625-99-5 1,3-dimethyl-5,6-diphenylpyrimidin-2,4-dion 

Relevant articles and documents

Preparation of zinc organometallics derived from nucleosides and nucleic acid bases and Pd(0) catalyzed coupling with aryl iodides

5-Iodouracil and 6-iodopurine derivatives readily insert zinc dust (25°C or 70°C) in THF or DMAC affording zincated nucleic acid base derivatives which undergo efficient palladium catalyzed cross-coupling reactions with aryl iodides in good yields. This r

Preparation method of 1,3-dimethyl-5-phenyluracil

The invention relates to a preparation method of 1,3-dimethyl-5-phenyluracil. The preparation method includes mixing phenylamine, water and a fluoboric acid water solution, dropwise adding a water solution of sodium nitrite with stirring for 1-2 hours at 0-5 DEG C and performing suction filtration so as to obtain phenyldiazonium tetrafluoroborate; at the room temperature, adding 1,3-dimethyluracil and a copper salt catalyst into a solvent with stirring and mixing, adding the phenyldiazonium tetrafluoroborate in batches, stirring to react for 8-12 hours after addition is finished, and conducting separation and purification so as to obtain the 1,3-dimethyl-5-phenyluracil. The preparation method has the advantages of simplicity in operation, short reaction route, less reaction time, high product yield and suitability for industrialized production.

Switching the regioselectivity of direct C-H arylation of 1,3-Dimethyluracil

An interesting dichotomy in the regioselectivity and mechanism of direct C-H arylation of 1,3-dimethyluracil was observed. Its Pd-catalyzed reactions with diverse aryl halides in the absence of Cui lead preferentially to 5-aryluracils, while reactions in