55407-46-0Relevant articles and documents
Synthesis, 1D and 2D NMR spectral assignments, and stereochemical studies of some 4,8,9,10-tetraaryl-1,3-diazaadamantan-6-one oximes
Vengatesh,Sundaravadivelu
, p. 1929 - 1939 (2019)
A series of 4,8,9,10-tetraaryl-1,3-diazaadamantan-6-one oximes (4a-4e) have been synthesized. 1H and 13C NMR spectra of these oximes were recorded. Chemical shifts have been assigned and the stereochemistry of the compounds was established using 1D and 2D NMR spectral data. A detailed spectral investigation was carried out for one of the representative compounds (4a) with COSY, NOESY, HMQC, HMBC, DEPT-135, and N NMR spectral data. The NMR result clearly indicated the twin chair conformation of the two piperidine rings. The NMR results proved the axial orientation of two aryl groups (C4 and C10) in one piperidine ring and equatorial orientation of two aryl groups (C8 and C9) in another piperidine ring. The effect of allylic (A1,3) interaction between the oxime hydroxyl group and H-5e has been observed. Long-range coupling between H-10e and H-2 which are in ‘W’ arrangement is noted.
Synthesis of diversely substituted adamantanes as a new class of antimicrobial agent
Balaji,Sarveswari,Vijayakumar
, p. 6765 - 6776 (2015/02/19)
Abstract 4,8,9,10-tetraaryl-1,3-diazatricyclo[3.3.1.1]decan-6-ones are synthesized and reduced into its 4,8,9,10-tetraaryl-1,3-diazatricyclo[3.3.1.1]decan-6-ols (6a-m) with NaBH4 in methanol (2v), benzene (1v) mixture as the solvent system. These compounds are characterized using spectral data such as IR, 1H-NMR, and 13C-NMR data. These synthesized compounds are screened for their antimicrobial activity and were found to be effective anti-bacterials.
